Donald Lei1, Muhammad Yousaf1, Sherief R Janmohamed1, Paras P Vakharia2, Rishi Chopra3, Rajeev Chavda4, Sylvie Gabriel4, Ryan Sacotte5, Kevin R Patel6, Vivek Singam7, Supriya Immaneni1, Robert Kantor3, Derek Y Hsu8, Jonathan I Silverberg9. 1. Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois. 2. Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas. 3. State University of New York Downstate Medical Center, Brooklyn, New York. 4. Galderma SA | Rx Strategy & Innovation Group, La Tour-de-Peliz, Switzerland. 5. Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI USA. 6. Department of Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts. 7. Department of Internal Medicine, Weiss Memorial Hospital, Chicago, Illinois. 8. Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 9. Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC, and Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address: JonathanISilverberg@gmail.com.
Abstract
BACKGROUND: The optimal approaches for monitoring sleep disturbances in adults with atopic dermatitis (AD) is not established. Multiple patient-reported outcome measures for AD and itch have sleep-related items. These items have not been validated previously. OBJECTIVE: Assess the measurement properties of sleep-related items from the Patient-Oriented Eczema Measure (POEM), SCORing AD (SCORAD), 5-dimensions of itch (5D), and ItchyQOL in adults with AD. METHODS: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n = 115). RESULTS: There was modest overlap and weak-moderate concordance of responses to the different assessments. Regarding concurrent validity, POEM-sleep, SCORAD-sleep, 5D-sleep, and ItchyQOL-sleep showed moderate correlations with each other. Regarding convergent validity, all items showed moderate correlation with total POEM, but weak correlations with Eczema Area and Severity Index (EASI), objective and total SCORAD, moderate to strong correlations with mean ItchyQOL and Dermatology Life Quality Index (DLQI), but poor or no significant correlation with Numeric Rating Scale (NRS) for worst or average itch. Regarding discriminant validity, all items showed significant and stepwise increases with increasing self-reported and physician-reported AD severity (Kruskal-Wallis, P < .01 for all). Floor effects were observed for POEM-sleep (n = 53, 46.1%), SCORAD-sleep (n = 28, 24.4%), 5D-sleep (n = 41, 35.7%), and ItchyQOL-sleep (n = 33, 28.7%); no ceiling effects were observed. Change in sleep-related item scores showed moderate strong correlations with change in POEM, 5Ditch, mean ItchyQOL, DLQI, objective and total SCORAD, and EASI, but inconsistent correlations with change of itch severity. CONCLUSION: Sleep-related items from POEM, SCORAD, 5D and ItchyQOL showed good validity and responsiveness to monitor sleep disturbances in adult AD patients.
BACKGROUND: The optimal approaches for monitoring sleep disturbances in adults with atopic dermatitis (AD) is not established. Multiple patient-reported outcome measures for AD and itch have sleep-related items. These items have not been validated previously. OBJECTIVE: Assess the measurement properties of sleep-related items from the Patient-Oriented Eczema Measure (POEM), SCORing AD (SCORAD), 5-dimensions of itch (5D), and ItchyQOL in adults with AD. METHODS: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n = 115). RESULTS: There was modest overlap and weak-moderate concordance of responses to the different assessments. Regarding concurrent validity, POEM-sleep, SCORAD-sleep, 5D-sleep, and ItchyQOL-sleep showed moderate correlations with each other. Regarding convergent validity, all items showed moderate correlation with total POEM, but weak correlations with Eczema Area and Severity Index (EASI), objective and total SCORAD, moderate to strong correlations with mean ItchyQOL and Dermatology Life Quality Index (DLQI), but poor or no significant correlation with Numeric Rating Scale (NRS) for worst or average itch. Regarding discriminant validity, all items showed significant and stepwise increases with increasing self-reported and physician-reported AD severity (Kruskal-Wallis, P < .01 for all). Floor effects were observed for POEM-sleep (n = 53, 46.1%), SCORAD-sleep (n = 28, 24.4%), 5D-sleep (n = 41, 35.7%), and ItchyQOL-sleep (n = 33, 28.7%); no ceiling effects were observed. Change in sleep-related item scores showed moderate strong correlations with change in POEM, 5Ditch, mean ItchyQOL, DLQI, objective and total SCORAD, and EASI, but inconsistent correlations with change of itch severity. CONCLUSION: Sleep-related items from POEM, SCORAD, 5D and ItchyQOL showed good validity and responsiveness to monitor sleep disturbances in adult ADpatients.
Authors: L A Beck; J I Silverberg; E L Simpson; G Yosipovitch; L Eckert; I Guillemin; Z Chen; M Ardeleanu; S Plaum; N Graham; M Ruddy; G Pirozzi; A Gadkari Journal: J Eur Acad Dermatol Venereol Date: 2020-09-07 Impact factor: 6.166
Authors: J Puelles; F Fofana; D Rodriguez; J I Silverberg; A Wollenberg; C Dias Barbosa; M Vernon; R Chavda; S Gabriel; C Piketty Journal: Br J Dermatol Date: 2021-11-17 Impact factor: 11.113