| Literature DB >> 31830499 |
Mateusz Sikora1, Bartosz Kopeć1, Katarzyna Piotrowska1, Andrzej Pawlik2.
Abstract
Allograft inflammatory factor-1 (AIF-1) is a 17 kDa calcium-binding protein produced by monocytes, macrophages, and lymphocytes; its synthesis is induced by INF-γ. The AIF-1 gene is located in the major histocompatibility complex (MHC) class III region on chromosome 6p21.3, surrounded by surface glycoprotein genes and complement cascade protein genes as well as TNF-α, TNF-β, and NF-κB genes. Increased expression of AIF-1 was observed in several diseases, including endometriosis, breast cancer, atherosclerosis, rheumatoid arthritis, and fibrosis. In this review, we summarise the role of AIF-1 in allograft rejection and the pathogenesis of diseases.Entities:
Keywords: Allograft inflammatory factor-1; Atherosclerosis; Graft; Rheumatoid arthritis
Year: 2019 PMID: 31830499 DOI: 10.1016/j.imlet.2019.12.002
Source DB: PubMed Journal: Immunol Lett ISSN: 0165-2478 Impact factor: 3.685