Taro Kojima1, Toshifumi Matsui2,3, Yusuke Suzuki4, Yasushi Takeya5, Naoki Tomita6, Koichi Kozaki2, Masafumi Kuzuya7, Hiromi Rakugi5, Hiroyuki Arai6, Masahiro Akishita1. 1. Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. 2. Department of Geriatric Medicine, Kyorin University School of Medicine, Tokyo, Japan. 3. Oouchi Hospital, Tokyo, Japan. 4. Department of Quality and Patient Safety, Nagoya University Hospital, Nagoya, Japan. 5. Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan. 6. Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. 7. Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Abstract
AIM: To investigate the characteristics of adverse drug reactions (ADR) and their risk factors among very old patients in five geriatric wards in Japan. METHODS: A retrospective observational multicenter study was carried out to investigate factors related to ADR in older inpatients from geriatric wards of five university hospitals in Japan. Data including drugs profile and short-form comprehensive geriatric assessment were obtained from medical charts. ADR were identified from geriatrician's reports. For each ADR, symptoms and causal drugs were clarified, and factors associated with ADR were analyzed statistically. RESULTS: In 1155 patients (52.5% women, mean age 82.8 ± 7.0 years), the proportion with ADR was 15.4%. There was a great variety of signs and symptoms of ADR, and a great variety of drugs suspected to be the cause of ADR. On multiple logistic regression analysis, ADR was significantly associated with an increase in drugs (odds ratio 1.11, 95% CI 1.07-1.16) and emergency admission (odds ratio 2.76, 95% CI 1.82-4.15). Receiver operating characteristic curve analysis showed that the optimal cut-off number of drugs for predicting ADR was ≥7. CONCLUSIONS: In geriatric inpatients, polypharmacy (especially ≥7 drugs) and emergency admission were associated with ADR. Because there was a great variety of ADR in the study, clinicians must consider reviewing all drugs to prevent adverse drugs reactions during admission in this vulnerable population. Geriatr Gerontol Int 2019; ••: ••-••. Geriatr Gerontol Int 2020; 20: 144-149.
AIM: To investigate the characteristics of adverse drug reactions (ADR) and their risk factors among very old patients in five geriatric wards in Japan. METHODS: A retrospective observational multicenter study was carried out to investigate factors related to ADR in older inpatients from geriatric wards of five university hospitals in Japan. Data including drugs profile and short-form comprehensive geriatric assessment were obtained from medical charts. ADR were identified from geriatrician's reports. For each ADR, symptoms and causal drugs were clarified, and factors associated with ADR were analyzed statistically. RESULTS: In 1155 patients (52.5% women, mean age 82.8 ± 7.0 years), the proportion with ADR was 15.4%. There was a great variety of signs and symptoms of ADR, and a great variety of drugs suspected to be the cause of ADR. On multiple logistic regression analysis, ADR was significantly associated with an increase in drugs (odds ratio 1.11, 95% CI 1.07-1.16) and emergency admission (odds ratio 2.76, 95% CI 1.82-4.15). Receiver operating characteristic curve analysis showed that the optimal cut-off number of drugs for predicting ADR was ≥7. CONCLUSIONS: In geriatric inpatients, polypharmacy (especially ≥7 drugs) and emergency admission were associated with ADR. Because there was a great variety of ADR in the study, clinicians must consider reviewing all drugs to prevent adverse drugs reactions during admission in this vulnerable population. Geriatr Gerontol Int 2019; ••: ••-••. Geriatr Gerontol Int 2020; 20: 144-149.
Authors: Tadele Mekuriya Yadesa; Freddy Eric Kitutu; Serawit Deyno; Patrick Engeu Ogwang; Robert Tamukong; Paul E Alele Journal: SAGE Open Med Date: 2021-08-18
Authors: Tatiana A Marins; Alexandre R Marra; Michael B Edmond; Ligia Regina Prystaj Colombo; Sthephanie Favalli Vieira; Fernanda de Oliveira Xavier; Alessandra Gomes Chauvin; João Renato Rebello Pinho; Silvana M de Almeida; Marcelino Souza Durão Junior Journal: Antimicrob Steward Healthc Epidemiol Date: 2021-10-28