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Literature DB >> 3182913

Procoagulant activity of gastric, colorectal, and renal cancer is factor VII-dependent.

M Szczepański¹, K Bardadin, J Zawadzki, W Pypno.

Abstract

The PA of GC, CC, and RC extracts was assayed by the recalcification of human normal or F VII-DP, and the PA of normal tissue was also determined. The PA of normal tissue was higher than that of the cancer tissues in all groups of specimens. Substitution of normal plasma by F VII-DP resulted in significant depression of the PA and the differences in the PA between the normal and cancer tissue samples disappeared. Preincubation of normal and cancer tissue extracts with the cysteine proteinase inhibitors, mercuric chloride and iodoacetamide, did not affect the PA of these extracts. We conclude that the PA of the investigated cancer extracts is factor VII-dependent and can be related to the presence of tissue factor within cancer tissue.

Entities: Chemical Disease Species

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Year: 1988 PMID： 3182913 DOI： 10.1007/bf00391504

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

18 in total

1. Cancer procoagulant A: a factor X activating procoagulant from malignant tissue.

Authors: S G Gordon; J J Franks; B Lewis
Journal: Thromb Res Date: 1975-02 Impact factor: 3.944

2. Coagulation-cancer interaction in situ in renal cell carcinoma.

Authors: L R Zacharski; V A Memoli; S M Rousseau
Journal: Blood Date: 1986-08 Impact factor: 22.113

3. Plasminogen activators, plasminogen activator inhibitors and procoagulant analyzed in twenty human tumor cell lines.

Authors: J F Cajot; E K Kruithof; W D Schleuning; B Sordat; F Bachmann
Journal: Int J Cancer Date: 1986-11-15 Impact factor: 7.396

Review 4. Tissue factor: a vitamin K-dependent clotting factor?

Authors: L R Zacharski; R Rosenstein; P G Phillips
Journal: Ann N Y Acad Sci Date: 1981 Impact factor: 5.691

5. Procoagulant activity of mouse and human cultured cells following various types of transformation.

Authors: L Curatolo; G Alessio; C Gambacorti Passerini; B Casali; L Morasca; N Semeraro; M B Donati
Journal: Int J Cancer Date: 1985-03-15 Impact factor: 7.396

6. Tissue factor activity of normal and neoplastic cells: quantitation and species specificity.

Authors: J L Kadish; K M Wenc; H F Dvorak
Journal: J Natl Cancer Inst Date: 1983-03 Impact factor: 13.506

Review 7. Fibrin as a component of the tumor stroma: origins and biological significance.

Authors: H F Dvorak; D R Senger; A M Dvorak
Journal: Cancer Metastasis Rev Date: 1983 Impact factor: 9.264

8. Hemostatic abnormalities in malignancy, a prospective study of one hundred eight patients. Part I. Coagulation studies.

Authors: N C Sun; W M McAfee; G J Hum; J M Weiner
Journal: Am J Clin Pathol Date: 1979-01 Impact factor: 2.493

Procoagulant activity of gastric, colorectal, and renal cancer is factor VII-dependent.

1. Cancer procoagulant A: a factor X activating procoagulant from malignant tissue.

2. Coagulation-cancer interaction in situ in renal cell carcinoma.

3. Plasminogen activators, plasminogen activator inhibitors and procoagulant analyzed in twenty human tumor cell lines.

Review 4. Tissue factor: a vitamin K-dependent clotting factor?

5. Procoagulant activity of mouse and human cultured cells following various types of transformation.

6. Tissue factor activity of normal and neoplastic cells: quantitation and species specificity.

Review 7. Fibrin as a component of the tumor stroma: origins and biological significance.

8. Hemostatic abnormalities in malignancy, a prospective study of one hundred eight patients. Part I. Coagulation studies.

9. A factor X-activating cysteine protease from malignant tissue.

10. Procoagulant and fibrinolytic activities of gastric and colorectal cancer.

1. Trousseau's syndrome.

2. Coagulopathy in the prostate cancer patient: prevalence and clinical relevance.

Review 3. Tissue factor as a tumor procoagulant.

4. Tissue factor expression as a possible determinant of thromboembolism in ovarian cancer.

5. The significance of measuring monocyte tissue factor activity in patients with breast and colorectal cancer.

6. Procoagulant activity may be a marker of the malignant phenotype in experimental prostate cancer.