Literature DB >> 3182910

Antimetastatic effect of bromelain with or without its proteolytic and anticoagulant activity.

S Batkin1, S J Taussig, J Szekerezes.   

Abstract

Bromelain, a pineapple-derived plant product, added to C57Bl/6 mice laboratory chow decreased lung metastasis of Lewis lung cancer cells implanted s.c. This antimetastatic potential was demonstrated by both the active and inactive bromelain with or without proteolytic, anticoagulant properties.

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Year:  1988        PMID： 3182910     DOI： 10.1007/bf00391501

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  11 in total

1.  A study of the mechanism by which anticoagulation with warfarin inhibits blood-borne metastases.

Authors:  J M Brown
Journal:  Cancer Res       Date:  1973-06       Impact factor: 12.701

2.  Heme proteins. VI. Crystalline pineapple peroxidase B.

Authors:  C Beaudreau; K T Yasunobu
Journal:  Biochemistry       Date:  1966-04       Impact factor: 3.162

3.  Modulation of pulmonary metastasis (Lewis lung carcinoma) by bromelain, an extract of the pineapple stem (Ananas comosus)

Authors:  S Batkin; S Taussig; J Szekerczes
Journal:  Cancer Invest       Date:  1988       Impact factor: 2.176

4.  Anticoagulant treatment of rats with Walker 256 carcinosarcoma.

Authors:  C A Owen
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553

5.  Biological diversity in metastatic neoplasms: origins and implications.

Authors:  I J Fidler; I R Hart
Journal:  Science       Date:  1982-09-10       Impact factor: 47.728

6.  Effects of antiplatelet agents on pulmonary metastases.

Authors:  H Bando; T Yamashita; E Tsubura
Journal:  Gan       Date:  1984-03

7.  Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin.

Authors:  M Sato; T Narisawa; M Sano; T Takahashi; A Goto
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

8.  Inhibition of tumor cell metastasis by modulation of the vascular prostacyclin/thromboxane A2 system.

Authors:  K V Honn
Journal:  Clin Exp Metastasis       Date:  1983 Apr-Jun       Impact factor: 5.150

Review 9.  Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update.

Authors:  S J Taussig; S Batkin
Journal:  J Ethnopharmacol       Date:  1988 Feb-Mar       Impact factor: 4.360

10.  The effect of prostaglandin modulators on prostate tumor growth and metastasis.

Authors:  J R Drago; H A Al-Mondhiry
Journal:  Anticancer Res       Date:  1984 Nov-Dec       Impact factor: 2.480
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  5 in total

Review 1.  Systemic enzyme therapy in oncology: effect and mode of action.

Authors:  J Leipner; R Saller
Journal:  Drugs       Date:  2000-04       Impact factor: 9.546

2.  Bromelain-Functionalized Multiple-Wall Lipid-Core Nanocapsules: Formulation, Chemical Structure and Antiproliferative Effect Against Human Breast Cancer Cells (MCF-7).

Authors:  Catiúscia P Oliveira; Willian A Prado; Vladimir Lavayen; Sabrina L Büttenbender; Aline Beckenkamp; Bruna S Martins; Diogo S Lüdtke; Leandra F Campo; Fabiano S Rodembusch; Andréia Buffon; Adalberto Pessoa; Silvia S Guterres; Adriana R Pohlmann
Journal:  Pharm Res       Date:  2016-12-15       Impact factor: 4.200

3.  Bromelain reversibly inhibits invasive properties of glioma cells.

Authors:  B B Tysnes; H R Maurer; T Porwol; B Probst; R Bjerkvig; F Hoover
Journal:  Neoplasia       Date:  2001 Nov-Dec       Impact factor: 5.715

4.  Isolation and partial characterization of basic proteinases from stem bromelain.

Authors:  T Harrach; K Eckert; K Schulze-Forster; R Nuck; D Grunow; H R Maurer
Journal:  J Protein Chem       Date:  1995-01

5.  Bromelain surface modification increases the diffusion of silica nanoparticles in the tumor extracellular matrix.

Authors:  Alessandro Parodi; Seth G Haddix; Nima Taghipour; Shilpa Scaria; Francesca Taraballi; Armando Cevenini; Iman K Yazdi; Claudia Corbo; Roberto Palomba; Sm Z Khaled; Jonathan O Martinez; Brandon S Brown; Lucas Isenhart; Ennio Tasciotti
Journal:  ACS Nano       Date:  2014-09-17       Impact factor: 15.881
  5 in total

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