Literature DB >> 31828267

Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors.

Yasuaki Kimura1, Zhaoma Shu1, Mika Ito2, Naoko Abe1, Kosuke Nakamoto1, Fumiaki Tomoike3, Satoshi Shuto4, Yoshihiro Ito5, Hiroshi Abe6.   

Abstract

We herein report a new approach for RNA interference, so-called "build-up RNAi" approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors. The advantages of using these circular RNA formats for RNAi were presented in aspects of immunogenicity and cellular uptake.

Entities:  

Year:  2019        PMID： 31828267     DOI： 10.1039/c9cc04872c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Photoactivatable Circular Caged Oligonucleotides for Transcriptome In Vivo Analysis (TIVA).

Authors:  Linlin Yang; Dora von Trentini; HyunBum Kim; Jai-Yoon Sul; James H Eberwine; Ivan J Dmochowski
Journal:  ChemPhotoChem       Date:  2021-06-23

2.  Caspase-Activated Oligonucleotide Probe.

Authors:  Linlin Yang; James H Eberwine; Ivan J Dmochowski
Journal:  Bioconjug Chem       Date:  2020-08-24       Impact factor: 4.774

3.  Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.

Authors:  Hartmut Jahns; Rohan Degaonkar; Peter Podbevsek; Swati Gupta; Anna Bisbe; Krishna Aluri; John Szeto; Pawan Kumar; Sarah LeBlanc; Tim Racie; Christopher R Brown; Adam Castoreno; Dale C Guenther; Vasant Jadhav; Martin A Maier; Janez Plavec; Martin Egli; Muthiah Manoharan; Ivan Zlatev
Journal:  Nucleic Acids Res       Date:  2021-10-11       Impact factor: 16.971

Review 4.  Photochemical modifications for DNA/RNA oligonucleotides.

Authors:  Amirrasoul Tavakoli; Jung-Hyun Min
Journal:  RSC Adv       Date:  2022-02-24       Impact factor: 3.361

5.  Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing.

Authors:  Xueli Zhang; Amu Gubu; Jianfei Xu; Ning Yan; Wenbo Su; Di Feng; Qian Wang; Xinjing Tang
Journal:  Molecules       Date:  2022-07-08       Impact factor: 4.927

6.  Multimerized self-assembled caged two-in-one siRNA nanoparticles for photomodulation of RNAi-induced gene silencing.

Authors:  Changmai Chen; Nannan Jing; Zhongyu Wang; Yu Zhang; Wei Chen; Xinjing Tang
Journal:  Chem Sci       Date:  2020-10-12       Impact factor: 9.825

Review 7.  Conditionally Activated ("Caged") Oligonucleotides.

Authors:  Linlin Yang; Ivan J Dmochowski
Journal:  Molecules       Date:  2021-03-09       Impact factor: 4.411

Review 8.  Noncoding RNA therapeutics - challenges and potential solutions.

Authors:  Melanie Winkle; Sherien M El-Daly; Muller Fabbri; George A Calin
Journal:  Nat Rev Drug Discov       Date:  2021-06-18       Impact factor: 84.694
  8 in total

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