| Literature DB >> 31826469 |
Zahra Mahmoudi1, Javad Mohammadnejad2, Sajad Razavi Bazaz3, Ali Abouei Mehrizi1, Masoud Saidijam4, Rassoul Dinarvand5, Majid Ebrahimi Warkiani6, Masoud Soleimani7.
Abstract
The field of cartilage tissue engineering has been evolved in the last decade and a myriad of scaffolding biomaterials and bioactive agents have been proposed. Controlled release of growth factors encapsulated in the polymeric nanomaterials has been of interest notably for the repair of damaged articular cartilage. Here, we proposed an on-chip hydrodynamic flow focusing microfluidic approach for synthesis of alginate nanogels loaded with the transforming growth factor beta 3 (TGF-β3) through an ionic gelation method in order to achieve precise release profile of these bioactive agents during chondrogenic differentiation of mesenchymal stem cells (MSCs). Alginate nanogels with adjustable sizes were synthesized by fine-tuning the flow rate ratio (FRR) in the microfluidic device consisting of cross-junction microchannels. The result of present study showed that the proposed approach can be a promising tool to synthesize bioactive -loaded polymeric nanogels for applications in drug delivery and tissue engineering.Entities:
Keywords: Alginate nanogels; Chondrogenesis; Computational fluid dynamics (CFD); Growth factor delivery; Microfluidics
Mesh：
Substances：
Year: 2019 PMID： 31826469 DOI： 10.1016/j.carbpol.2019.115551
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381