Mustafa Kerem Calgin1, Yeliz Cetinkol2. 1. Ordu University, Ordu, Turkey. mkcalgin@gmail.com. 2. Ordu University, Ordu, Turkey. dryelizcetinkol@gmail.com.
Abstract
INTRODUCTION: The aim of this study was to establish local resistance profiles of Candida species isolated from various clinical specimens by identifying isolates and determining their susceptibilities to commonly used antifungal agents. METHODOLOGY: All isolates were identified to species level and amphotericin B, flucytosine, fluconazole, voriconazole, caspofungin and micafungin antifungal susceptibility testing was performed using Vitek 2 Compact Advanced Expert System (AES). RESULTS: The specimens consisted of 152 urines (69%), 49 blood (22%), 15 sputum (7%) and 4 wound (2%) samples. Of the 220 isolated Candida strains, the most prevalent species were Candida albicans (43.3%), Candida tropicalis (25%) and Candida parapsilosis (13.7%). In blood specimens C. parapsilosis was the dominant species (43%), followed by C. albicans (32.5%) and C. tropicalis (12.2%). Overall resistance to amphotericin B, flucytosine, fluconazole, voriconazole, caspofungin and micafungin was 7.3%, 10%, 9.4%, 7.3%, 2% and 6.5%, respectively. CONCLUSIONS: Due to the increase in patient populations at risk of Candida infections, rational treatment planning and resistance rates should be checked along with antifungal susceptibility testing on C. albicans, C. tropicalis and C. parapsilosis isolates.
INTRODUCTION: The aim of this study was to establish local resistance profiles of Candida species isolated from various clinical specimens by identifying isolates and determining their susceptibilities to commonly used antifungal agents. METHODOLOGY: All isolates were identified to species level and amphotericin B, flucytosine, fluconazole, voriconazole, caspofungin and micafungin antifungal susceptibility testing was performed using Vitek 2 Compact Advanced Expert System (AES). RESULTS: The specimens consisted of 152 urines (69%), 49 blood (22%), 15 sputum (7%) and 4 wound (2%) samples. Of the 220 isolated Candida strains, the most prevalent species were Candida albicans (43.3%), Candida tropicalis (25%) and Candida parapsilosis (13.7%). In blood specimens C. parapsilosis was the dominant species (43%), followed by C. albicans (32.5%) and C. tropicalis (12.2%). Overall resistance to amphotericin B, flucytosine, fluconazole, voriconazole, caspofungin and micafungin was 7.3%, 10%, 9.4%, 7.3%, 2% and 6.5%, respectively. CONCLUSIONS: Due to the increase in patient populations at risk of Candida infections, rational treatment planning and resistance rates should be checked along with antifungal susceptibility testing on C. albicans, C. tropicalis and C. parapsilosis isolates.
Authors: Marie Andrea Laetitia Huët; Li Wen Wong; Calvin Bok Sun Goh; Md Hamed Hussain; Nazmul Hasan Muzahid; Jacky Dwiyanto; Shaun Wen Huey Lee; Qasim Ayub; Daniel Reidpath; Sui Mae Lee; Sadequr Rahman; Joash Ban Lee Tan Journal: World J Microbiol Biotechnol Date: 2021-06-08 Impact factor: 3.312