Literature DB >> 3182402

Structure-activity relationship of a novel antitumor ansamycin antibiotic trienomycin A and related compounds.

S Funayama1, Y Anraku, A Mita, Z B Yang, K Shibata, K Komiyama, I Umezawa, S Omura.   

Abstract

Various derivatives of trienomycin A (1) were prepared and tested for cytocidal activities. All the derivatives except for 22-O-methyltrienomycin A (5) showed reduced cytotoxicity compared with 1. It is concluded that the existence of a triene moiety, free 13-OH and an acyl group at C-11 owe important role for cytocidal activity.

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Year:  1988        PMID： 3182402     DOI： 10.7164/antibiotics.41.1223

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

1.  Monoenomycin: A Simplified Trienomycin A Analogue that Manifests Anticancer Activity.

Authors:  Gary E L Brandt; Brian S J Blagg
Journal:  ACS Med Chem Lett       Date:  2011-10-13       Impact factor: 4.345

2.  Metallacycle-Mediated Cross-Coupling in Natural Product Synthesis.

Authors:  Natasha F O'Rourke; Matthew J Kier; Glenn C Micalizio
Journal:  Tetrahedron       Date:  2016-09-07       Impact factor: 2.457

Review 3.  Conformation-activity relationships of polyketide natural products.

Authors:  Erik M Larsen; Matthew R Wilson; Richard E Taylor
Journal:  Nat Prod Rep       Date:  2015-08       Impact factor: 13.423

4.  Synthesis of the cytotrienin A core via metal catalyzed C-C coupling.

Authors:  Michael Rössle; David J Del Valle; Michael J Krische
Journal:  Org Lett       Date:  2011-02-16       Impact factor: 6.005

5.  Total synthesis of (+)-trienomycins A and F via C-C bond-forming hydrogenation and transfer hydrogenation.

Authors:  David J Del Valle; Michael J Krische
Journal:  J Am Chem Soc       Date:  2013-07-17       Impact factor: 15.419

6.  Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.

Authors:  Khaled A Shaaban; Xiachang Wang; Sherif I Elshahawi; Larissa V Ponomareva; Manjula Sunkara; Gregory C Copley; James C Hower; Andrew J Morris; Madan K Kharel; Jon S Thorson
Journal:  J Nat Prod       Date:  2013-08-15       Impact factor: 4.050

7.  New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164.

Authors:  Yaqin Fan; Cong Wang; Liping Wang; Arthit Chairoungdua; Pawinee Piyachaturawat; Peng Fu; Weiming Zhu
Journal:  Mar Drugs       Date:  2018-08-15       Impact factor: 5.118
  7 in total

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