Lu-Ping Li1, Bastien Milani2, Menno Pruijm2, Orly Kohn3, Stuart Sprague1, Bradley Hack1, Pottumarthi Prasad4. 1. NorthShore University HealthSystem, 2650 Ridge Avenue, Walgreen Jr. Building, Suite G507, Evanston, IL, 60201, USA. 2. Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. 3. University of Chicago Medical Center, University of Chicago, Chicago, USA. 4. NorthShore University HealthSystem, 2650 Ridge Avenue, Walgreen Jr. Building, Suite G507, Evanston, IL, 60201, USA. pprasad@northshore.org.
Abstract
OBJECTIVE: Blood oxygenation level dependent (BOLD) MRI technique is used to evaluate changes in intra-renal oxygenation in chronic kidney disease (CKD). The purpose of this study was to evaluate if the novel twelve layer concentric objects (TLCO) method has advantages over the manually defined regions of interest (ROI) analysis. METHODS AND MATERIALS: Existing renal BOLD MRI data acquired before and after furosemide on a 3 T scanner from 41 CKD patients and 13 age matched healthy controls were analyzed using TLCO method and compared with previously reported ROI analysis. RESULTS: Regional R2* measurements were strongly correlated between the two methods, while ΔR2* was moderately correlated. Medullary R2* by ROI analysis showed higher values compared to R2*_Inner by TLCO, probably due to the contributions from the cortex to R2*_Inner. R2*_Slope and Δ(R2*_Slope), unique parameters based on the TLCO method provided the most significant differences between stage 3a CKD patients and controls and were correlated with eGFR. DISCUSSION: There was a high degree of agreement between the two methods in terms of regional R2* measurements and both methods did not show differences between moderate CKD patients and controls. However, R2*_Slope and Δ(R2*_Slope) showed the largest sensitivity in distinguishing CKD from controls.
OBJECTIVE: Blood oxygenation level dependent (BOLD) MRI technique is used to evaluate changes in intra-renal oxygenation in chronic kidney disease (CKD). The purpose of this study was to evaluate if the novel twelve layer concentric objects (TLCO) method has advantages over the manually defined regions of interest (ROI) analysis. METHODS AND MATERIALS: Existing renal BOLD MRI data acquired before and after furosemide on a 3 T scanner from 41 CKD patients and 13 age matched healthy controls were analyzed using TLCO method and compared with previously reported ROI analysis. RESULTS: Regional R2* measurements were strongly correlated between the two methods, while ΔR2* was moderately correlated. Medullary R2* by ROI analysis showed higher values compared to R2*_Inner by TLCO, probably due to the contributions from the cortex to R2*_Inner. R2*_Slope and Δ(R2*_Slope), unique parameters based on the TLCO method provided the most significant differences between stage 3a CKD patients and controls and were correlated with eGFR. DISCUSSION: There was a high degree of agreement between the two methods in terms of regional R2* measurements and both methods did not show differences between moderate CKD patients and controls. However, R2*_Slope and Δ(R2*_Slope) showed the largest sensitivity in distinguishing CKD from controls.
Entities:
Keywords:
BOLD-MRI; Chronic kidney disease; Furosemide; Oxygenation; Region of interest; TLCO
Authors: Pottumarthi V Prasad; Jon Thacker; Lu-Ping Li; Muhammad Haque; Wei Li; Heather Koenigs; Ying Zhou; Stuart M Sprague Journal: PLoS One Date: 2015-10-02 Impact factor: 3.240
Authors: Lu-Ping Li; Jon M Thacker; Wei Li; Bradley Hack; Chi Wang; Orly Kohn; Stuart M Sprague; Pottumarthi V Prasad Journal: Am J Nephrol Date: 2021-01-28 Impact factor: 3.754