OBJECTIVE: To investigate the possible association between salivary CRP, IL-1β, and IL-6 levels, depression/anxiety and migraine, and tension type headache (TTH) in saliva of these patients. METHOD: A longitudinal prospective study was conducted on 30 migraineurs, 30 TTH patients, and 30 age-matched healthy controls. Anxiety and depression were measured by using the Hamilton Anxiety Rating Scale (HAM-A), and the Beck Depression Inventory (BDI). Salivary IL-6, IL-1β, and CRP were collected in distinct time points as A: headache-free period, B: during headache, C: 1 day after headache attack, and measured by using ELISA kits. RESULTS: No significant differences were found in time variation of CRP, IL-1β, and IL-6 levels between migraine and TTH (p > 0.05). IL1-β had the highest discriminative value (area under the curve = 0.924, p value < 0.001), and then CRP (area under the curve = 0.763, p value < 0.001) and IL-6 (area under the curve = 0.537, p value = 0.58). CRP and IL-6 were negatively correlated with HAM-A and BDI scores. CONCLUSION: IL1-β had the highest discriminative value between headache patients and controls compared with CRP and IL-6. CRP and IL-6 were correlated with lower symptom scores of anxiety and depression prior or immediately after the headache period in patients groups.
OBJECTIVE: To investigate the possible association between salivary CRP, IL-1β, and IL-6 levels, depression/anxiety and migraine, and tension type headache (TTH) in saliva of these patients. METHOD: A longitudinal prospective study was conducted on 30 migraineurs, 30 TTHpatients, and 30 age-matched healthy controls. Anxiety and depression were measured by using the Hamilton Anxiety Rating Scale (HAM-A), and the Beck Depression Inventory (BDI). Salivary IL-6, IL-1β, and CRP were collected in distinct time points as A: headache-free period, B: during headache, C: 1 day after headache attack, and measured by using ELISA kits. RESULTS: No significant differences were found in time variation of CRP, IL-1β, and IL-6 levels between migraine and TTH (p > 0.05). IL1-β had the highest discriminative value (area under the curve = 0.924, p value < 0.001), and then CRP (area under the curve = 0.763, p value < 0.001) and IL-6 (area under the curve = 0.537, p value = 0.58). CRP and IL-6 were negatively correlated with HAM-A and BDI scores. CONCLUSION: IL1-β had the highest discriminative value between headachepatients and controls compared with CRP and IL-6. CRP and IL-6 were correlated with lower symptom scores of anxiety and depression prior or immediately after the headache period in patients groups.
Authors: Thamires Sales Ribeiro; Luciana Salles Branco de Almeida; Vandilson Pinheiro Rodrigues; Caio Marcio Barros de Oliveira; Ed Carlos Rey Moura; Luciana Maia Moura Naves; Lidio Gonçalves Lima Neto; Leonardo Victor Galvão Moreira; Emanuel Cabral Pereira; Plínio da Cunha Leal Journal: Rev Assoc Med Bras (1992) Date: 2022-09 Impact factor: 1.712
Authors: Andrea Cruz; Maria Vieira; Ana R Mesquita; Adriana Sampaio; Inês Mendes-Pinto; Isabel Soares; Paulo P Freitas Journal: Front Neurosci Date: 2022-09-26 Impact factor: 5.152
Authors: César Fernández-de-Las-Peñas; Víctor Gómez-Mayordomo; David García-Azorín; Domingo Palacios-Ceña; Lidiane L Florencio; Angel L Guerrero; Valentín Hernández-Barrera; María L Cuadrado Journal: Front Hum Neurosci Date: 2021-06-28 Impact factor: 3.169