Beatriz Pombas1, Eva Rodríguez1, Juan Sánchez2, Aleksandar Radosevic2, Javier Gimeno3, Marcos Busto2, Clara Barrios1, Laia Sans1, Julio Pascual1, María José Soler4,5. 1. Department of Nephrology, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. 2. Department of Radiology, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. 3. Department of Pathology, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. 4. Department of Nephrology, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain, mjsoler01@gmail.com. 5. Department of Nephrology, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain, mjsoler01@gmail.com.
Abstract
INTRODUCTION: Percutaneous renal biopsy (PRB) of native kidneys is an important tool for diagnosis and management of renal disease. In this study, we analyzed the success, safety, and risk complications of PRB in our center. METHODS: A retrospective review of ultrasound-guided PRB done at our institution from January 1998 to December 2017 was performed. Clinical and laboratory data were collected for 661 PRBs. Statistical analysis was performed using the Mann-Whitney U test for continuous variable and chi-square test for categorical variables. Multivariate analysis using logistic regression was performed to assess factors associated with increased risk of complications after PRB. RESULTS: The median age was 56 (42-68) years old, the majority were male (64%) and white (82%). Ten glomeruli were present in 63.5% of PRBs. Overall, the rate of complications was 16.6%, where 15.1% of them were minor complications and 1.5% were major complications. Perinephritic hematoma accounted for the minor complication that occurred most frequently, whereas the need of a blood transfusion was the prevalent for major complications. By multivariate analysis, increased activated partial thromboplastin time (aPTT; OR 1.11, 95% CI 1.035-1.180) and prebiopsy lower hemoglobin (Hgb; OR 1.61, 95% CI 1.086-2.304) were identified as independent risk factors for major complications. In addition, older patients (OR 1.057, 95% CI 1.001-1.117) were identified as an independent risk factor for blood transfusion requirement. CONCLUSION: The current risk of complications after native PRB is low. Major complications are most common in case of increased aPTT and decreased Hgb baseline level.
INTRODUCTION: Percutaneous renal biopsy (PRB) of native kidneys is an important tool for diagnosis and management of renal disease. In this study, we analyzed the success, safety, and risk complications of PRB in our center. METHODS: A retrospective review of ultrasound-guided PRB done at our institution from January 1998 to December 2017 was performed. Clinical and laboratory data were collected for 661 PRBs. Statistical analysis was performed using the Mann-Whitney U test for continuous variable and chi-square test for categorical variables. Multivariate analysis using logistic regression was performed to assess factors associated with increased risk of complications after PRB. RESULTS: The median age was 56 (42-68) years old, the majority were male (64%) and white (82%). Ten glomeruli were present in 63.5% of PRBs. Overall, the rate of complications was 16.6%, where 15.1% of them were minor complications and 1.5% were major complications. Perinephritic hematoma accounted for the minor complication that occurred most frequently, whereas the need of a blood transfusion was the prevalent for major complications. By multivariate analysis, increased activated partial thromboplastin time (aPTT; OR 1.11, 95% CI 1.035-1.180) and prebiopsy lower hemoglobin (Hgb; OR 1.61, 95% CI 1.086-2.304) were identified as independent risk factors for major complications. In addition, older patients (OR 1.057, 95% CI 1.001-1.117) were identified as an independent risk factor for blood transfusion requirement. CONCLUSION: The current risk of complications after native PRB is low. Major complications are most common in case of increased aPTT and decreased Hgb baseline level.
Authors: Aksharaa Anpalahan; Eva Malacova; Katharine Hegerty; Andrew Malett; Dwarakanathan Ranganathan; Helen G Healy; Pedro Henrique Franca Gois Journal: Kidney360 Date: 2021-06-16
Authors: Shane A Bobart; Heedeok Han; Shahrzad Tehranian; An S De Vriese; Juan Carlos Leon Roman; Sanjeev Sethi; Ladan Zand; Cristina Andrades Gomez; Callen D Giesen; Maria Jose Soler; Andrew S Bomback; Fernando C Fervenza Journal: Clin J Am Soc Nephrol Date: 2021-11-15 Impact factor: 8.237
Authors: Eun Song Kang; Soo Min Ahn; Ji Seon Oh; Hyosang Kim; Won Seok Yang; Yong-Gil Kim; Chang-Keun Lee; Bin Yoo; Seokchan Hong Journal: Clin Rheumatol Date: 2022-10-06 Impact factor: 3.650
Authors: Shepherd Kajawo; Udeme Ekrikpo; Mothusi Walter Moloi; Jean Jacques Noubiap; Mohamed A Osman; Ugochi S Okpechi-Samuel; Andre Pascal Kengne; Aminu K Bello; Ikechi G Okpechi Journal: Kidney Int Rep Date: 2020-11-03
Authors: Kristina K Deonaraine; Philip M Carlucci; Andrea Fava; Jessica Li; David Wofsy; Judith A James; Chaim Putterman; Betty Diamond; Anne Davidson; Derek M Fine; Jose Monroy-Trujillo; Mohamed G Atta; Kristin Haag; Deepak A Rao; William Apruzzese; H Michael Belmont; Peter M Izmirly; Ming Wu; Sean Connery; Fernanda Payan-Schober; Richard A Furie; Celine C Berthier; Maria Dall'Era; Kerry Cho; Diane L Kamen; Kenneth Kalunian; Jennifer Anolik; Mariko Ishimori; Michael H Weisman; Michelle A Petri; Jill P Buyon Journal: Lupus Sci Med Date: 2021-08