| Literature DB >> 31821990 |
Hamed Mortazavi1, Banafsheh Nikfar2, Seyed-Alireza Esmaeili3, Fatemeh Rafieenia4, Ehsan Saburi5, Shahla Chaichian6, Mohammad Ali Heidari Gorji7, Amir Abbas Momtazi-Borojeni8.
Abstract
Gynaecological disorders, such as cervical, ovarian, and endometrial cancers are the second most prevalent cancer types in women worldwide. Therapeutic approaches for gynaecological cancers involve chemotherapy, radiation, and surgery. However, lifespan is not improved, and novel medications are required. Among various phytochemicals, berberine, a well-known natural product, has been shown to be a promising cancer chemopreventive agent. Pharmacokinetics, safety, and efficacy of berberine have been investigated in the several experiments against numerous diseases. Here, we aimed to provide a literature review from available published investigations showing the anticancer effects of berberine and its various synthetic analogues against gynaecological disorders, including cervical, ovarian, and endometrial cancers. In conclusion, berberine has been found to efficiently inhibit viability, proliferation, and migration of cancer cells, mainly, via induction of apoptosis by both mitochondrial dependent and -independent pathways. Additionally, structural modification of berberine showed that berberine analogues can improve its antitumor effects against gynaecological cancers.Entities:
Keywords: Apoptosis; Berberine; Gynecological cancers
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Year: 2019 PMID： 31821990 DOI： 10.1016/j.ejmech.2019.111951
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514