| Literature DB >> 31821814 |
Francesco Giorgino1, Irene Caruso2, Julia Moellmann3, Michael Lehrke4.
Abstract
SGLT-2 inhibitors and most GLP-1 receptor agonists demonstrated cardiovascular superiority and reduction of cardiovascular and overall mortality. These results stand as a turning point in the management of diabetes, shifting the focus from controlling glucose levels to mastering the extra-glycemic effects of these new drugs. This narrative review will discuss recent CVOT with focus on SGLT-2 inhibitors and GLP-1 receptor agonists to distinguish relevant patients' characteristics as potential predictors for therapeutic efficacy. It will also examine their efficacy and safety, the differences in their cardiovascular and renal benefits, aiming to convey clinical suggestions for everyday practice.Entities:
Keywords: Cardiovascular; Chronic kidney disease; GLP-1 receptor agonists; Heart failure; SGLT-2 inhibitors
Year: 2019 PMID: 31821814 DOI: 10.1016/j.metabol.2019.154045
Source DB: PubMed Journal: Metabolism ISSN: 0026-0495 Impact factor: 8.694