Literature DB >> 3182082

Hormonal modulation of sex differences in resistance to Leishmania major systemic infections.

B A Mock1, C A Nacy.   

Abstract

Differences in susceptibility to intravenously inoculated Leishmania major were observed in male and female mice of the BALB/cAnPt, DBA/2N, and DBA/2J strains and (BALB/cAnPt x DBA/2N)F1 hybrids. In all cases, males had significantly higher liver parasite burdens than females. Orchidectomy of BALB/c males resulted in a 20% decrease in the number of parasites in the liver compared with either normal or sham-gonadectomized controls. Additionally, testosterone treatment of female BALB/c mice resulted in an 88% increase in the number of liver amastigotes. These results suggest that the hormone testosterone can modulate systemic L. major infections in BALB/c mice.

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Year:  1988        PMID： 3182082      PMCID： PMC259743          DOI： 10.1128/iai.56.12.3316-3319.1988

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  33 in total

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Review 5.  Sexual dimorphism in the liver.

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Journal:  Annu Rev Physiol       Date:  1983       Impact factor: 19.318

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Authors:  G Norstedt; R Palmiter
Journal:  Cell       Date:  1984-04       Impact factor: 41.582

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Authors:  H C Greenblatt; D L Rosenstreich
Journal:  Infect Immun       Date:  1984-01       Impact factor: 3.441

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Authors:  Y Weinstein; S Ran; S Segal
Journal:  J Immunol       Date:  1984-02       Impact factor: 5.422

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Authors:  J M Blackwell; C Hale; M B Roberts; O M Ulczak; F Y Liew; J G Howard
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846
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  26 in total

Review 1.  Sex-associated hormones and immunity to protozoan parasites.

Authors:  C W Roberts; W Walker; J Alexander
Journal:  Clin Microbiol Rev       Date:  2001-07       Impact factor: 26.132

Review 2.  Hormones and the resistance of women to paracoccidioidomycosis.

Authors:  Jata Shankar; Angela Restrepo; Karl V Clemons; David A Stevens
Journal:  Clin Microbiol Rev       Date:  2011-04       Impact factor: 26.132

3.  Paracoccidioidomycosis in a woman with idiopathic hirsutism.

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4.  Androgen-dependent immune modulation in parasitic infection.

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6.  Effect of sex steroids on Babesia microti infection in mice.

Authors:  Mizuki Sasaki; Yoshito Fujii; Maya Iwamoto; Hiromi Ikadai
Journal:  Am J Trop Med Hyg       Date:  2012-12-18       Impact factor: 2.345

7.  Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia.

Authors:  A Hsu; D M Aronoff; J Phipps; D Goel; P Mancuso
Journal:  Clin Exp Immunol       Date:  2007-09-05       Impact factor: 4.330

8.  The effect of ageing on human lymphocyte subsets: comparison of males and females.

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9.  Sex differences in host resistance to Mycobacterium marinum infection in mice.

Authors:  Y Yamamoto; H Saito; T Setogawa; H Tomioka
Journal:  Infect Immun       Date:  1991-11       Impact factor: 3.441

10.  Potential for sexual conflict assessed via testosterone-mediated transcriptional changes in liver and muscle of a songbird.

Authors:  Mark P Peterson; Kimberly A Rosvall; Charlene A Taylor; Jacqueline Ann Lopez; Jeong-Hyeon Choi; Charles Ziegenfus; Haixu Tang; John K Colbourne; Ellen D Ketterson
Journal:  J Exp Biol       Date:  2013-11-06       Impact factor: 3.312
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