Literature DB >> 31820688

Hypodopaminergia and "Precision Behavioral Management" (PBM): It is a Generational Family Affair.

Lyle Fried1,2, Edward J Modestino1,3, David Siwicki1, Lisa Lott1, Panayotis K Thanos1,4, David Baron1,5, Rajendra D Badgaiyan1,6, Jessica V Ponce1, James Giordano7, William B Downs8, Marjorie C Gondré-Lewis9, Steinberg Bruce3, Eric R Braverman10, Brent Boyett11, Kenneth Blum1,5,7,8,10,11,12,13,14,15.   

Abstract

BACKGROUND/AIMS: This case series presents the novel Genetic Addiction Risk Score (GARS®) coupled with a customized pro-dopamine regulator matched to polymorphic reward genes having a hypodopaminergic risk.
METHODS: The proband is a female with a history of drug abuse and alcoholism. She experienced a car accident under the influence and voluntarily entered treatment. Following an assessment, she was genotyped using the GARS, and started a neuronutrient with a KB220 base indicated by the identified polymorphisms. She began taking it in April 2018 and continues.
RESULTS: She had success in recovery from Substance Use Disorder (SUD) and improvement in socialization, family, economic status, well-being, and attenuation of Major Depression. She tested negative over the first two months in treatment and a recent screening. After approximately two months, her parents also decided to take the GARS and started taking the recommended variants. The proband's father (a binge drinker) and mother (no SUD) both showed improvement in various behavioral issues. Finally, the proband's biological children were also GARS tested, showing a high risk for SUD.
CONCLUSION: This three-generation case series represents an example of the impact of genetic information coupled with an appropriate DNA guided "Pro-Dopamine Regulator" in recovery and enhancement of life. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  Genetic Addiction Risk Score (GARS®); Precision Addiction Managementzzm321990(PAM®); Precision Behavioral Management (PBM®); Substance Use Disorder (SUD); brain reward circuitry; hypodopaminergia; pro-dopamine regulator (KB220Z).

Year:  2020        PMID： 31820688     DOI： 10.2174/1389201021666191210112108

Source DB:  PubMed          Journal:  Curr Pharm Biotechnol        ISSN： 1389-2010            Impact factor:   2.837


  16 in total

1.  Dopaminylation in Psychostimulant Use Disorder Protects Against Psychostimulant Seeking Behavior by Normalizing Nucleus Accumbens (NAc) Dopamine Expression.

Authors:  Kenneth Blum; Mark S Gold; Jean L Cadet; David Baron; Abdalla Bowirrat; Panayotis K Thanos; Raymond Brewer; Rajendra D Badgaiyan; Marjorie C Gondré-Lewis
Journal:  Curr Psychopharmacol       Date:  2021-01-08

2.  Researching Mitigation of Alcohol Binge Drinking in Polydrug Abuse: KCNK13 and RASGRF2 Gene(s) Risk Polymorphisms Coupled with Genetic Addiction Risk Severity (GARS) Guiding Precision Pro-Dopamine Regulation.

Authors:  Kenneth Blum; Mark S Brodie; Subhash C Pandey; Jean Lud Cadet; Ashim Gupta; Igor Elman; Panayotis K Thanos; Marjorie C Gondre-Lewis; David Baron; Shan Kazmi; Abdalla Bowirrat; Marcelo Febo; Rajendra D Badgaiyan; Eric R Braverman; Catherine A Dennen; Mark S Gold
Journal:  J Pers Med       Date:  2022-06-20

3.  Translational and Molecular Cytoarchitectural Genetic Guided Therapy to Induce Dopamine Homeostatic Neuro-signaling in Reward Deficiency and Associated Drug and Behavioral Addiction Seeking: A 60 Year Sojourn the Future is Now.

Authors:  Kenneth Blum; Rajendra D Badgaiyan
Journal:  EC Psychol Psychiatr       Date:  2021-07-29

4.  Should We Embrace the Incorporation of Genetically Guided "Dopamine Homeostasis" in the Treatment of Reward Deficiency Syndrome (RSD) as a Frontline Therapeutic Modality?

Authors:  Kenneth Blum; Ali Raza; Tiffany Schultz; Rehan Jalali; Richard Green; Raymond Brewer; Panyotis K Thanos; Thomas McLaughlin; David Baron; Abdalla Bowirrat; Igor Elman; B William Downs; Debasis Bagchi; Rajendra D Badgaiyan
Journal:  Acta Sci Neurol       Date:  2021-02-02

5.  Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis.

Authors:  Kenneth Blum; Jag Khalsa; Jean Lud Cadet; David Baron; Abdalla Bowirrat; Brent Boyett; Lisa Lott; Raymond Brewer; Marjorie Gondré-Lewis; Gregory Bunt; Shan Kazmi; Mark S Gold
Journal:  Front Psychiatry       Date:  2021-03-30       Impact factor: 4.157

6.  Hypothesizing in the Face of the Opioid Crisis Coupling Genetic Addiction Risk Severity (GARS) Testing with Electrotherapeutic Nonopioid Modalities Such as H-Wave Could Attenuate Both Pain and Hedonic Addictive Behaviors.

Authors:  Ashim Gupta; Abdalla Bowirrat; Luis Llanos Gomez; David Baron; Igor Elman; John Giordano; Rehan Jalali; Rajendra D Badgaiyan; Edward J Modestino; Mark S Gold; Eric R Braverman; Anish Bajaj; Kenneth Blum
Journal:  Int J Environ Res Public Health       Date:  2022-01-04       Impact factor: 3.390

7.  Hypothesizing High Negative Emotionality as a Function of Genetic Addiction Risk Severity (GARS) Testing in Alcohol Use Disorder (AUD).

Authors:  Kenneth Blum; Richard Green; Jessica Smith; Luis Llanos-Gomez; David Baron; Rajendra D Badgaiyan
Journal:  J Syst Integr Neurosci       Date:  2020-11-14

8.  Molecular neuro-biological and systemic health benefits of achieving dopamine homeostasis in the face of a catastrophic pandemic (COVID- 19): A mechanistic exploration.

Authors:  B W Downs; K Blum; D Bagchi; S Kushner; M Bagchi; J M Galvin; McG Lewis; D Siwicki; R Brewer; B Boyett; D Baron; J Giordano; R D Badgaiyan
Journal:  J Syst Integr Neurosci       Date:  2020-04-30

Review 9.  Neurological correlates of brain reward circuitry linked to opioid use disorder (OUD): Do homo sapiens acquire or have a reward deficiency syndrome?

Authors:  Mark S Gold; David Baron; Abdalla Bowirrat; Kenneth Blum
Journal:  J Neurol Sci       Date:  2020-09-15       Impact factor: 3.181

Review 10.  A Novel Precision Approach to Overcome the "Addiction Pandemic" by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration.

Authors:  Kenneth Blum; Shan Kazmi; Edward J Modestino; Bill William Downs; Debasis Bagchi; David Baron; Thomas McLaughlin; Richard Green; Rehan Jalali; Panayotis K Thanos; Igor Elman; Rajendra D Badgaiyan; Abdalla Bowirrat; Mark S Gold
Journal:  J Pers Med       Date:  2021-03-16
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