Liane Correia-Costa1,2,3, Franz Schaefer4, Alberto Caldas Afonso5,6,7, Sofia Correia5,8, João Tiago Guimarães5,9, António Guerra10,11, Henrique Barros5,8, Ana Azevedo5,8. 1. EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal. lianecosta@icbas.up.pt. 2. Department of Pediatric Nephrology, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto, Porto, Portugal. lianecosta@icbas.up.pt. 3. Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal. lianecosta@icbas.up.pt. 4. Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany. 5. EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal. 6. Department of Pediatric Nephrology, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário do Porto, Porto, Portugal. 7. Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal. 8. Public Health and Forensic Sciences and Medical Education Department, Faculty of Medicine, University of Porto, Porto, Portugal. 9. Department of Clinical Pathology, Centro Hospitalar São João & Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal. 10. Division of Pediatric Nutrition, Integrated Pediatric Hospital, Centro Hospitalar Universitário São João, Porto, Portugal. 11. Department of Gynecology-Obstetrics and Pediatrics, Faculty of Medicine, University of Porto, Porto, Portugal.
Abstract
BACKGROUND: Prenatal ethanol exposure has been shown to reduce nephron endowment in animal models, but the effect of alcohol during human pregnancy on postnatal kidney function has not been explored. We aim to investigate the potential association of maternal alcohol consumption during pregnancy with the offspring renal function, considering potential confounding by intrauterine growth and children's current nutritional status. METHODS: Prospective longitudinal study in a random sample of 1093 children from a population-based birth cohort. Anthropometrics and estimated glomerular filtration rate (eGFR) were assessed at 7 years of age. Multiple linear regression models were fitted, adjusting for child's gender, age, birthweight, and maternal age, education, prepregnancy nutritional status, and smoking. RESULTS: Thirteen percent of mothers consumed alcohol during pregnancy. At 7 years of age, eGFR was significantly lower in children with prenatal alcohol exposure (134 ± 17 vs.138 ± 16 mL/min/1.73m2, p = 0.014). The effect was dose dependent and only present in overweight and obese children, among whom adjusted eGFR was -6.6(-12.0 to -1.1)mL/min/1.73m2 and -11.1(-21.3 to -1.2)mL/min/1.73m2 in those exposed to ≤ 40 g and to > 40 g of alcohol per week, respectively, compared to no consumption (ptrend = 0.002). CONCLUSIONS: Prenatal alcohol exposure has a dose-dependent adverse effect on renal function at school age in overweight and obese children.
BACKGROUND: Prenatal ethanol exposure has been shown to reduce nephron endowment in animal models, but the effect of alcohol during human pregnancy on postnatal kidney function has not been explored. We aim to investigate the potential association of maternal alcohol consumption during pregnancy with the offspring renal function, considering potential confounding by intrauterine growth and children's current nutritional status. METHODS: Prospective longitudinal study in a random sample of 1093 children from a population-based birth cohort. Anthropometrics and estimated glomerular filtration rate (eGFR) were assessed at 7 years of age. Multiple linear regression models were fitted, adjusting for child's gender, age, birthweight, and maternal age, education, prepregnancy nutritional status, and smoking. RESULTS: Thirteen percent of mothers consumed alcohol during pregnancy. At 7 years of age, eGFR was significantly lower in children with prenatal alcohol exposure (134 ± 17 vs.138 ± 16 mL/min/1.73m2, p = 0.014). The effect was dose dependent and only present in overweight and obesechildren, among whom adjusted eGFR was -6.6(-12.0 to -1.1)mL/min/1.73m2 and -11.1(-21.3 to -1.2)mL/min/1.73m2 in those exposed to ≤ 40 g and to > 40 g of alcohol per week, respectively, compared to no consumption (ptrend = 0.002). CONCLUSIONS: Prenatal alcohol exposure has a dose-dependent adverse effect on renal function at school age in overweight and obesechildren.
Authors: Karen M Moritz; Marc Q Mazzuca; Andrew L Siebel; Amy Mibus; Debbie Arena; Marianne Tare; Julie A Owens; Mary E Wlodek Journal: J Physiol Date: 2009-04-09 Impact factor: 5.182
Authors: Sarah L White; Vlado Perkovic; Alan Cass; Choon Lan Chang; Neil R Poulter; Tim Spector; Leigh Haysom; Jonathan C Craig; Isa Al Salmi; Steven J Chadban; Rachel R Huxley Journal: Am J Kidney Dis Date: 2009-04-01 Impact factor: 8.860