Literature DB >> 3181950

Mucin histochemistry of heterotopic gastric mucosa of the upper esophagus in adults: possible pathogenic implications.

W V Bogomoletz1, K Geboes, P Feydy, S Nasca, N Ectors, C Rigaud.   

Abstract

The mucin profile of 24 endoscopic biopsies of heterotopic gastric mucosa (HGM) of the upper esophagus in adults and a control group of ten cases of Meckel's diverticula containing heterotopic gastric mucosa were studied with two combined histochemical methods: alcian blue pH 2.5/PAS and high iron diamine/alcian blue pH 2.5. The clinical and light microscopic features of the 24 HGM cases were also reviewed. In addition to overall secretion of neutral mucins by the 24 HGM cases, mucin histochemistry showed prominent secretion of acidic mucins in 19 of 24 HGM cases (79%), with sulphomucins in 11 of 24 HGM cases (45.8%). This mucin profile of HGM was unlike that of either normal gastric mucosa or heterotopic gastric mucosa in Meckel's diverticula. Moreover, a comparison between the mucin profile and clinical features of HGM and Barrett's esophagus showed certain similarities. The data suggest a physiopathologic link between HGM and Barrett's esophagus.

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Year:  1988        PMID： 3181950     DOI： 10.1016/s0046-8177(88)80285-5

Source DB:  PubMed          Journal:  Hum Pathol        ISSN： 0046-8177            Impact factor:   3.466


  8 in total

1.  Campylobacter-like organisms in heterotopic gastric mucosa of the upper oesophagus.

Authors:  J F Flejou; F Potet; G Molas; W V Bogomoletz; S Nasca; C Rigaud; P Feydy; N Ectors; K Geboes
Journal:  J Clin Pathol       Date:  1990-11       Impact factor: 3.411

2.  The role of mucin in GERD and its complications.

Authors:  Yaron Niv; Ronnie Fass
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2011-11-08       Impact factor: 46.802

Review 3.  Adenocarcinoma of the upper esophagus arising in cervical ectopic gastric mucosa: rare evidence of malignant potential of so-called "inlet patch".

Authors:  G Y Lauwers; G V Scott; J N Vauthey
Journal:  Dig Dis Sci       Date:  1998-04       Impact factor: 3.199

Review 4.  Cervical inlet patch: new insights into diagnosis and endoscopic therapy.

Authors:  Radu Rusu; Sauid Ishaq; Terry Wong; Jason M Dunn
Journal:  Frontline Gastroenterol       Date:  2017-11-09

5.  Cervical inlet patch-optical coherence tomography imaging and clinical significance.

Authors:  Chao Zhou; Tejas Kirtane; Tsung-Han Tsai; Hsiang-Chieh Lee; Desmond C Adler; Joseph M Schmitt; Qin Huang; James G Fujimoto; Hiroshi Mashimo
Journal:  World J Gastroenterol       Date:  2012-05-28       Impact factor: 5.742

6.  Heterotopic Gastric Mucosa in the Proximal Esophagus: Prospective Study and Systematic Review on Relationships with Endoscopic Findings and Clinical Data.

Authors:  Marcin Romańczyk; Krzysztof Budzyń; Tomasz Romańczyk; Magdalena Lesińska; Mateusz Koziej; Marek Hartleb; Marek Waluga
Journal:  Dysphagia       Date:  2022-07-09       Impact factor: 3.438

Review 7.  Clinical significance of heterotopic gastric mucosal patch of the proximal esophagus.

Authors:  Vui Heng Chong
Journal:  World J Gastroenterol       Date:  2013-01-21       Impact factor: 5.742

8.  The prevalence of gastric heterotopia of the proximal esophagus is underestimated, but preneoplasia is rare - correlation with Barrett's esophagus.

Authors:  Ulrich Peitz; Michael Vieth; Matthias Evert; Jovana Arand; Albert Roessner; Peter Malfertheiner
Journal:  BMC Gastroenterol       Date:  2017-07-12       Impact factor: 3.067
  8 in total

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