Lei Sheng1, Jinyuan Shi2, Bo Han3, Bin Lv1, Luchuan Li1, Bo Chen1, Nan Liu1, Yingting Cao4, Andrew G Turner5, Qingdong Zeng6. 1. Department of Thyroid Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. 2. Department of Thyroid Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China; School of Medicine, Shandong University, Jinan, Shondong, China. 3. Department of Pathology, Qilu Hospital of Shandong University, Jinan, Shondong, China. 4. School of Medicine, The University of Adelaide, Adelaide, SA, Australia. 5. UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia. 6. Department of Thyroid Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic address: zqd596@sdu.edu.cn.
Abstract
BACKGROUND: Optimal management for papillary thyroid microcarcinoma (PTMC) remains controversial. The purpose of this study was to explore risk factors predictive of cervical lymph node metastasis in conventional PTMCs. METHODS: Conventional PTMC patients (n = 2,404) undergoing surgery between 2010 and 2017 were grouped and analyzed according to the positivity of cervical lymph node. RESULTS: Central lymph node (CLN) metastases and lateral lymph node (LLN) metastases were observed in 915 (38.1%) and 184 (7.7%) cases, respectively. Multivariate analysis found that male (odds ratio [OR] = 1.974, p < 0.001), younger age (OR = 1.601, p < 0.001), tumor size (OR = 1.935, p < 0.001), extrathyroidal extension (ETE) (OR = 1.647, p < 0.001), multifocality (OR = 1.416, p < 0.001), and intrathyroidal spreading (OR = 3.355, p < 0.001) predicted increased CLN metastasis. In particular, younger age, multifocality, and intrathyroidal spreading were significantly associated with a high number of CLN metastases (n ≥ 5). The presence of CLN metastasis was strongly associated with LLN metastasis (OR = 5.426, p < 0.001). CONCLUSION: Male, younger age, tumor size, ETE, multifocality, and intrathyroidal spreading predict increased CLN metastasis in PTMCs. In patients with suspicious lateral lymphadenopathy, the presence of CLN metastasis is independently associated with LLN metastasis.
BACKGROUND: Optimal management for papillary thyroid microcarcinoma (PTMC) remains controversial. The purpose of this study was to explore risk factors predictive of cervical lymph node metastasis in conventional PTMCs. METHODS: Conventional PTMCpatients (n = 2,404) undergoing surgery between 2010 and 2017 were grouped and analyzed according to the positivity of cervical lymph node. RESULTS: Central lymph node (CLN) metastases and lateral lymph node (LLN) metastases were observed in 915 (38.1%) and 184 (7.7%) cases, respectively. Multivariate analysis found that male (odds ratio [OR] = 1.974, p < 0.001), younger age (OR = 1.601, p < 0.001), tumor size (OR = 1.935, p < 0.001), extrathyroidal extension (ETE) (OR = 1.647, p < 0.001), multifocality (OR = 1.416, p < 0.001), and intrathyroidal spreading (OR = 3.355, p < 0.001) predicted increased CLN metastasis. In particular, younger age, multifocality, and intrathyroidal spreading were significantly associated with a high number of CLNmetastases (n ≥ 5). The presence of CLN metastasis was strongly associated with LLN metastasis (OR = 5.426, p < 0.001). CONCLUSION: Male, younger age, tumor size, ETE, multifocality, and intrathyroidal spreading predict increased CLN metastasis in PTMCs. In patients with suspicious lateral lymphadenopathy, the presence of CLN metastasis is independently associated with LLN metastasis.
Authors: Liguang Zhou; Gang Chen; Lei Sheng; Nan Liu; Bin Zhang; Qingdong Zeng; Bo Chen Journal: Cancer Manag Res Date: 2021-05-14 Impact factor: 3.989
Authors: Nan Liu; Yupeng Yang; Bo Chen; Luchuan Li; Qingdong Zeng; Lei Sheng; Bin Zhang; Weili Liang; Bin Lv Journal: Cancer Manag Res Date: 2020-12-14 Impact factor: 3.989
Authors: Fabio Medas; Gian Luigi Canu; Federico Cappellacci; Francesco Boi; Maria Letizia Lai; Enrico Erdas; Pietro Giorgio Calò Journal: Front Endocrinol (Lausanne) Date: 2020-08-25 Impact factor: 5.555