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Literature DB >> 31817470

The Roles of Sirtuin Family Proteins in Cancer Progression.

Erhu Zhao^1,2,3, Jianbing Hou^1,2,3, Xiaoxue Ke^1,2,3, Muhammad Nadeem Abbas^1,2,3, Saima Kausar^1,2,3, Lei Zhang^1,2,3, Hongjuan Cui^1,2,3.

Abstract

Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or deacylase activity and are linked to various cancer-related biological pathways as regulators of transcriptional progression. Sirtuins play fundamental roles in carcinogenesis and maintenance of the malignant phenotype, mainly participating in cancer cell viability, apoptosis, metastasis, and tumorigenesis. Although sirtuin family members have a high degree of homology, they may play different roles in various kinds of cancer. This review highlights their fundamental roles in tumorigenesis and cancer development and provides a critical discussion of their dual roles in cancer, namely, as tumor promoters or tumor suppressors.

Entities: CellLine Chemical Disease Gene Species

Keywords: Sirtuins; apoptosis; cell viability; metastasis; tumorigenesis

Year: 2019 PMID： 31817470 DOI： 10.3390/cancers11121949

Source DB: PubMed Journal: Cancers (Basel) ISSN： 2072-6694 Impact factor: 6.639

22 in total

Review 1. Sirtuin modulators: past, present, and future perspectives.

Authors: Francesco Fiorentino; Nicola Mautone; Martina Menna; Francesca D'Acunzo; Antonello Mai; Dante Rotili
Journal: Future Med Chem Date: 2022-05-18 Impact factor: 4.767

2. Single-Cell RNA Sequencing Unveils the Clonal and Transcriptional Landscape of Cutaneous T-Cell Lymphomas.

Authors: Alyxzandria M Gaydosik; Connor J Stonesifer; Alexandra E Khaleel; Larisa J Geskin; Patrizia Fuschiotti
Journal: Clin Cancer Res Date: 2022-06-13 Impact factor: 13.801

3. Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.

Authors: Vera Miranda-Gonçalves; Ana Lameirinhas; Catarina Macedo-Silva; João Lobo; Paula C Dias; Verónica Ferreira; Rui Henrique; Carmen Jerónimo
Journal: Cells Date: 2020-04-23 Impact factor: 6.600

4. Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis.

Authors: Arianna Bianchi; Letizia Marchetti; Zoe Hall; Henrique Lemos; Michele Vacca; Hannah Paish; Kile Green; Bronte Elliott; Dina Tiniakos; João F Passos; Diana Jurk; Derek A Mann; Caroline L Wilson
Journal: J Immunol Date: 2021-01-13 Impact factor: 5.422

Review 5. Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators.

Authors: Ewa Maria Kratz; Katarzyna Sołkiewicz; Adriana Kubis-Kubiak; Agnieszka Piwowar
Journal: Int J Mol Sci Date: 2021-01-10 Impact factor: 5.923

6. Correlation Analysis of Protein Expression of 10 HDAC/Sirtuin Isoenzymes with Sensitivities of 23 Anticancer Drugs in 17 Cancer Cell Lines and Potentiation of Drug Activity by Co-Treatment with HDAC Inhibitors.

Authors: Steven Behnisch-Cornwell; Christoph W Grathwol; Lukas Schulig; Anika Voigt; Daniel Baecker; Andreas Link; Patrick J Bednarski
Journal: Cancers (Basel) Date: 2021-12-31 Impact factor: 6.639

The Roles of Sirtuin Family Proteins in Cancer Progression.

Review 1. Sirtuin modulators: past, present, and future perspectives.

2. Single-Cell RNA Sequencing Unveils the Clonal and Transcriptional Landscape of Cutaneous T-Cell Lymphomas.

3. Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.

4. Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis.

Review 5. Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators.

6. Correlation Analysis of Protein Expression of 10 HDAC/Sirtuin Isoenzymes with Sensitivities of 23 Anticancer Drugs in 17 Cancer Cell Lines and Potentiation of Drug Activity by Co-Treatment with HDAC Inhibitors.

7. The study of sirtuins in breast cancer patients before and after radiotherapy

Review 8. The Role of Resveratrol in Mammalian Reproduction.

9. NUCKS promotes cell proliferation and suppresses autophagy through the mTOR-Beclin1 pathway in gastric cancer.

10. AntiGan: An Epinutraceutical Bioproduct with Antitumor Properties in Cultured Cell Lines.