David M Rosenberg1, Benjamin Onderdonk2, Nasma K Majeed3, Grace Guzman3, Yasser Farid4, Philip P Connell2, Christina H Son2,5. 1. College of Medicine, University of Illinois at Chicago, Chicago, Illinois. 2. Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois. 3. Department of Pathology, University of Illinois at Chicago, Chicago, Illinois. 4. Department of Orthopedic Surgery, University of Illinois at Chicago, Chicago, Illinois. 5. Department of Radiation Oncology, University of Illinois at Chicago, Chicago, Illinois.
Abstract
CASE: Heterotopic ossification (HO) is a pathological formation of bone in nonosseous tissue and is a common complication of orthopaedic procedures. Radiotherapy is often used to prevent HO despite the small risk of secondary malignancy. Here, we report a case of a patient who developed a periprosthetic, radiation-induced sarcoma after delivery of a single fraction of 7 Gy for HO prophylaxis. This sarcoma was found to lie entirely within the treatment field and occurred within 5 years of radiation. CONCLUSION: Appropriate counseling regarding radiation-induced sarcoma formation should be provided to patients considering radiotherapy for this HO prophylaxis.
CASE: Heterotopic ossification (HO) is a pathological formation of bone in nonosseous tissue and is a common complication of orthopaedic procedures. Radiotherapy is often used to prevent HO despite the small risk of secondary malignancy. Here, we report a case of a patient who developed a periprosthetic, radiation-induced sarcoma after delivery of a single fraction of 7 Gy for HO prophylaxis. This sarcoma was found to lie entirely within the treatment field and occurred within 5 years of radiation. CONCLUSION: Appropriate counseling regarding radiation-induced sarcoma formation should be provided to patients considering radiotherapy for this HO prophylaxis.