Hila Yahalom1, Simon Israeli-Korn2, Muli Linder3, Ziv Yekutieli4, Keren Tchelet Karlinsky4, Yarin Rubel5, Vered Livneh2, Tsvia Fay-Karmon2, Sharon Hassin-Baer2,6, Gilad Yahalom2,6. 1. Department of Psychiatry A1, Shaar Menashe Mental Health Center, Pardes Hanna. 2. Department of Neurology and Sagol Neuroscience Center and the Movement Disorders Institute, Chaim Sheba Medical Center, Tel-Hashomer. 3. Department of Psychiatry B, Shaar Menashe Mental Health Center, Pardes Hanna. 4. Montfort Brain Monitor LTD, Zichron Yaakov. 5. Department of Medical Engineering, Afeka, Tel-Aviv Academic College of Engineering. 6. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Abstract
OBJECTIVES: We aimed to characterize parkinsonian features and gait performance of psychiatric patients on neuroleptics (PPN) and to compare them to Parkinson's disease (PD) and healthy controls (HC). METHODS: Hospitalized PPN (n = 27) were recruited, examined, and rated for parkinsonian signs according to the motor part of the Movement Disorders Society Unified Parkinson's Disease Rating Scale and performed a 10-m "timed-up-and-go" (TUG) test with a smartphone-based motion capture system attached to their sternum. Gait parameters and mUPDRS scores were compared to those of consecutive age-matched PD patients (n = 18) and HC (n = 27). RESULTS: Psychiatric patients on neuroleptics exhibited parkinsonism (mUPDRS score range: 8-44) but less than that of PD patients (18.2 ± 9.2 vs 29.8 ± 10.3, P = 0.001). TUG times were slower for PPN and PD versus HC (total: 30.6 ± 7.6 seconds vs 30.0 ± 7.3 seconds vs 20.0 ± 3.2 seconds, straight walking: 10.6 ± 2.7 seconds vs 10.6 ± 2.4 seconds vs 6.8 ± 1.2 seconds) (P < 0.001), and cadence and step length were similar among PPN and PD and different from HC as well. Although their gait speed was slower than HC but similar to PD, PPN had lower mediolateral sway (4.3 ± 1.1 cm vs 6.7 ± 2.9 cm vs 6.9 ± 2.9 cm, respectively, P < 0.001) than both. CONCLUSIONS: Parkinsonism is very common in hospitalized PPN, but usually milder than that of PD. It seems that wearable sensor-based technology for assessing gait and balance may present a more sensitive and quantitative tool to detect clinical aspects of neuroleptic-induced parkinsonism than standard clinical ratings.
OBJECTIVES: We aimed to characterize parkinsonian features and gait performance of psychiatricpatients on neuroleptics (PPN) and to compare them to Parkinson's disease (PD) and healthy controls (HC). METHODS: Hospitalized PPN (n = 27) were recruited, examined, and rated for parkinsonian signs according to the motor part of the Movement Disorders Society Unified Parkinson's Disease Rating Scale and performed a 10-m "timed-up-and-go" (TUG) test with a smartphone-based motion capture system attached to their sternum. Gait parameters and mUPDRS scores were compared to those of consecutive age-matched PDpatients (n = 18) and HC (n = 27). RESULTS:Psychiatricpatients on neuroleptics exhibited parkinsonism (mUPDRS score range: 8-44) but less than that of PDpatients (18.2 ± 9.2 vs 29.8 ± 10.3, P = 0.001). TUG times were slower for PPN and PD versus HC (total: 30.6 ± 7.6 seconds vs 30.0 ± 7.3 seconds vs 20.0 ± 3.2 seconds, straight walking: 10.6 ± 2.7 seconds vs 10.6 ± 2.4 seconds vs 6.8 ± 1.2 seconds) (P < 0.001), and cadence and step length were similar among PPN and PD and different from HC as well. Although their gait speed was slower than HC but similar to PD, PPN had lower mediolateral sway (4.3 ± 1.1 cm vs 6.7 ± 2.9 cm vs 6.9 ± 2.9 cm, respectively, P < 0.001) than both. CONCLUSIONS:Parkinsonism is very common in hospitalized PPN, but usually milder than that of PD. It seems that wearable sensor-based technology for assessing gait and balance may present a more sensitive and quantitative tool to detect clinical aspects of neuroleptic-induced parkinsonism than standard clinical ratings.
Authors: Jamie L Adams; Karlo J Lizarraga; Emma M Waddell; Taylor L Myers; Stella Jensen-Roberts; Joseph S Modica; Ruth B Schneider Journal: Curr Neurol Neurosci Rep Date: 2021-03-03 Impact factor: 6.030
Authors: Whitley W Aamodt; Jacob G Dubroff; Gang Cheng; Betty Taylor; Stephanie Wood; John E Duda; James F Morley Journal: NPJ Parkinsons Dis Date: 2022-04-28