L Shi1,2, C Brunius2, I Johansson3,4, I A Bergdahl4,5, O Rolandsson4, B van Guelpen6,7, A Winkvist8,9, K Hanhineva10,11, R Landberg2,4. 1. From the, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, China. 2. Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. 3. Department of Odontology, Umeå University, Umeå, Sweden. 4. Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. 5. Department of Biobank Research, Umeå University, Umeå, Sweden. 6. Department of Radiation Sciences, Umeå University, Umeå, Sweden. 7. Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden. 8. Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg, Sweden. 9. Department of Public Health and Clinical Medicine, Sustainable Health, Umeå University, Umeå, Sweden. 10. LC-MS Metabolomics Center, Kuopio, Finland. 11. Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Abstract
BACKGROUND: Habitual coffee intake has been associated with a lower risk of developing type 2 diabetes (T2D), but few studies used biomarkers to reflect intake and investigated different coffee brews, that is boiled and filtered, separately. OBJECTIVES: To identify plasma metabolites associated with boiled or filtered coffee intake and to examine their association with T2D risk in Swedish adults. METHODS: In a case-control study nested within the Västerbotten Intervention Programme, baseline plasma samples from 421 case-control pairs and samples from a subset of 149 pairs at a 10-year follow-up were analysed using untargeted LC-MS metabolomics. We identified metabolites associated with food frequency questionnaires (FFQ)-estimated coffee intake and assessed odds ratios of T2D. RESULTS: In total, 24 and 32 metabolites were associated with boiled or filtered coffee intake. We determined robust metabolite panels for highly specific prediction of boiled or filtered coffee. We observed an inverse association between the metabolite panel of filtered coffee and T2D risk. No association with T2D was observed for the panel of boiled coffee intake. Similar results were observed for FFQ-estimated coffee intake. CONCLUSIONS: We identified plasma metabolites specifically associated with boiled or filtered coffee intake, which might be used as selective biomarkers. Our study supports a protective role of habitual intake of filtered coffee on T2D development. The lack of association for boiled coffee intake might be due to the lack of a protective effect of boiled coffee or due to the limited number of boiled coffee consumers in this population, but it warrants further investigation.
BACKGROUND: Habitual coffee intake has been associated with a lower risk of developing type 2 diabetes (T2D), but few studies used biomarkers to reflect intake and investigated different coffee brews, that is boiled and filtered, separately. OBJECTIVES: To identify plasma metabolites associated with boiled or filtered coffee intake and to examine their association with T2D risk in Swedish adults. METHODS: In a case-control study nested within the Västerbotten Intervention Programme, baseline plasma samples from 421 case-control pairs and samples from a subset of 149 pairs at a 10-year follow-up were analysed using untargeted LC-MS metabolomics. We identified metabolites associated with food frequency questionnaires (FFQ)-estimated coffee intake and assessed odds ratios of T2D. RESULTS: In total, 24 and 32 metabolites were associated with boiled or filtered coffee intake. We determined robust metabolite panels for highly specific prediction of boiled or filtered coffee. We observed an inverse association between the metabolite panel of filtered coffee and T2D risk. No association with T2D was observed for the panel of boiled coffee intake. Similar results were observed for FFQ-estimated coffee intake. CONCLUSIONS: We identified plasma metabolites specifically associated with boiled or filtered coffee intake, which might be used as selective biomarkers. Our study supports a protective role of habitual intake of filtered coffee on T2D development. The lack of association for boiled coffee intake might be due to the lack of a protective effect of boiled coffee or due to the limited number of boiled coffee consumers in this population, but it warrants further investigation.
Authors: Fenglei Wang; Megu Y Baden; Marta Guasch-Ferré; Clemens Wittenbecher; Jun Li; Yanping Li; Yi Wan; Shilpa N Bhupathiraju; Deirdre K Tobias; Clary B Clish; Lorelei A Mucci; A Heather Eliassen; Karen H Costenbader; Elizabeth W Karlson; Alberto Ascherio; Eric B Rimm; JoAnn E Manson; Liming Liang; Frank B Hu Journal: Diabetologia Date: 2022-04-08 Impact factor: 10.122
Authors: Jakub Morze; Clemens Wittenbecher; Lukas Schwingshackl; Anna Danielewicz; Andrzej Rynkiewicz; Frank B Hu; Marta Guasch-Ferré Journal: Diabetes Care Date: 2022-04-01 Impact factor: 17.152
Authors: Koen F Dekkers; Sergi Sayols-Baixeras; Marju Orho-Melander; Tove Fall; Gabriel Baldanzi; Christoph Nowak; Ulf Hammar; Diem Nguyen; Georgios Varotsis; Louise Brunkwall; Nynne Nielsen; Aron C Eklund; Jacob Bak Holm; H Bjørn Nielsen; Filip Ottosson; Yi-Ting Lin; Shafqat Ahmad; Lars Lind; Johan Sundström; Gunnar Engström; J Gustav Smith; Johan Ärnlöv Journal: Nat Commun Date: 2022-09-23 Impact factor: 17.694