Masayoshi Zaitsu1,2, Takumi Takeuchi3, Yasuki Kobayashi1, Ichiro Kawachi2. 1. Department of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 2. Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 3. Department of Urology, Kanto Rosai Hospital, Kawasaki, Japan.
Abstract
BACKGROUND: Even light to moderate alcohol consumption has been shown to increase cancer incidence. However, this association has not been well characterized in Japan. METHODS: Based on a nationwide, hospital-based data set (2005-2016), a multicenter case-control study was conducted (63,232 cancer cases and 63,232 controls matched for sex, age, admission date, and admitting hospital). The total amount of lifetime alcohol consumption (drink-years) was recalled for each patient by multiplication of the daily amount of standardized alcohol use (drinks per day) and the duration of drinking (years). Odds ratios (ORs) were estimated for overall and specific cancer sites via conditional logistic regression with restricted cubic splines, with adjustments made for smoking, occupational class, and comorbidities. Lifetime abstainers served as the reference group. RESULTS: Spline curves showed a dose-response association with overall cancer risk: the minimum risk was at 0 drink-years, and the OR at 10 drink-years was 1.05 (95% confidence interval [CI], 1.04-1.06). In comparison with lifetime abstainers, the OR for >0 to 20 drink-years was 1.06 (95% CI, 1.01-1.11). Those who drank 2 drinks or fewer per day had elevated odds for overall cancer risk across all duration-of-drinking categories. The same patterns were observed at light to moderate levels of drinking for most gastrointestinal/aerodigestive cancers as well as breast and prostate cancers. Analyses stratified by sex, different drinking/smoking behaviors, and occupational class mostly showed the same patterns for overall cancer incidence associated with light to moderate levels of drinking. CONCLUSIONS: In Japan, even light to moderate alcohol consumption appears to be associated with elevated cancer risks.
BACKGROUND: Even light to moderate alcohol consumption has been shown to increase cancer incidence. However, this association has not been well characterized in Japan. METHODS: Based on a nationwide, hospital-based data set (2005-2016), a multicenter case-control study was conducted (63,232 cancer cases and 63,232 controls matched for sex, age, admission date, and admitting hospital). The total amount of lifetime alcohol consumption (drink-years) was recalled for each patient by multiplication of the daily amount of standardized alcohol use (drinks per day) and the duration of drinking (years). Odds ratios (ORs) were estimated for overall and specific cancer sites via conditional logistic regression with restricted cubic splines, with adjustments made for smoking, occupational class, and comorbidities. Lifetime abstainers served as the reference group. RESULTS: Spline curves showed a dose-response association with overall cancer risk: the minimum risk was at 0 drink-years, and the OR at 10 drink-years was 1.05 (95% confidence interval [CI], 1.04-1.06). In comparison with lifetime abstainers, the OR for >0 to 20 drink-years was 1.06 (95% CI, 1.01-1.11). Those who drank 2 drinks or fewer per day had elevated odds for overall cancer risk across all duration-of-drinking categories. The same patterns were observed at light to moderate levels of drinking for most gastrointestinal/aerodigestive cancers as well as breast and prostate cancers. Analyses stratified by sex, different drinking/smoking behaviors, and occupational class mostly showed the same patterns for overall cancer incidence associated with light to moderate levels of drinking. CONCLUSIONS: In Japan, even light to moderate alcohol consumption appears to be associated with elevated cancer risks.
Authors: Carla A Scorza; Marcia Guimarães-Marques; Eduardo R C Girão; Mariana Nejm; Josef Finsterer; Manoel J B C Girão; Riad N Younes; Ronaldo R Laranjeira; Fulvio A Scorza Journal: Clinics (Sao Paulo) Date: 2020-05-08 Impact factor: 2.365
Authors: David I Conway; Jan Hovanec; Wolfgang Ahrens; Alastair Ross; Ivana Holcatova; Pagona Lagiou; Diego Serraino; Cristina Canova; Lorenzo Richiardi; Claire Healy; Kristina Kjaerheim; Gary J Macfarlane; Peter Thomson; Antonio Agudo; Ariana Znaor; Paul Brennan; Danièle Luce; Gwenn Menvielle; Isabelle Stucker; Simone Benhamou; Heribert Ramroth; Paolo Boffetta; Marta Vilensky; Leticia Fernandez; Maria Paula Curado; Ana Menezes; Alexander Daudt; Rosalina Koifman; Victor Wunsch-Filho; Amy Lee Yuan-Chin; Mia Hashibe; Thomas Behrens; Alex D McMahon Journal: J Epidemiol Community Health Date: 2021-02-23 Impact factor: 3.710