Jan Harnek1, Stefan James2, Bo Lagerqvist2. 1. Department of Coronary Heart Disease and Institute of Clinical Sciences, Lund University. 2. Department of Medical Sciences, Cardiology, Uppsala University.
Abstract
BACKGROUND: The incidence and short- and long-term outcomes of coronary artery perforation (CAP) are not well described.Methods and Results: We analyzed the characteristics and the short- and long-term outcomes of CAP among 243,149 patients undergoing percutaneous coronary interventions (PCI) from 2005 until 2017 in the national Swedish registry. We identified 1,008 cases of CAP with an incidence of 0.42%. Major adverse event rates were significantly higher in patients with CAP than non-CAP (P<0.001). The 1-year mortality rate was 16% vs. 5.5%, respectively, and the 12-year mortality rate was 52% vs. 34%. The restenosis rate was 5.2% vs. 3.1% and 17% vs. 9%, respectively. The target lesion revascularization rate was 4.2% vs. 2.6% and 10.5% vs. 7%. The stent thrombosis rate was numerically higher, 1.5% vs. 0.8% and 4.5 vs. 2.8%, with no stent thrombosis cases for equine pericardial stent grafts. Among the patients with tamponade a large proportion of cases occurred at the late stage (215/1,008, 21%), and most were not recognized in the cath-lab (167/215, 78%). The mortality rate for late tamponade was similar in patients suffering acute tamponade at 1 year (25.6% vs. 27%) or at 12 years (54% vs. 58%). CONCLUSIONS: CAP is associated with an early high excess in morbidity and mortality but with low risk of additional adverse events in the long term. Late tamponade is as deadly as acute tamponade.
BACKGROUND: The incidence and short- and long-term outcomes of coronary artery perforation (CAP) are not well described.Methods and Results: We analyzed the characteristics and the short- and long-term outcomes of CAP among 243,149 patients undergoing percutaneous coronary interventions (PCI) from 2005 until 2017 in the national Swedish registry. We identified 1,008 cases of CAP with an incidence of 0.42%. Major adverse event rates were significantly higher in patients with CAP than non-CAP (P<0.001). The 1-year mortality rate was 16% vs. 5.5%, respectively, and the 12-year mortality rate was 52% vs. 34%. The restenosis rate was 5.2% vs. 3.1% and 17% vs. 9%, respectively. The target lesion revascularization rate was 4.2% vs. 2.6% and 10.5% vs. 7%. The stent thrombosis rate was numerically higher, 1.5% vs. 0.8% and 4.5 vs. 2.8%, with no stent thrombosis cases for equine pericardial stent grafts. Among the patients with tamponade a large proportion of cases occurred at the late stage (215/1,008, 21%), and most were not recognized in the cath-lab (167/215, 78%). The mortality rate for late tamponade was similar in patients suffering acute tamponade at 1 year (25.6% vs. 27%) or at 12 years (54% vs. 58%). CONCLUSIONS: CAP is associated with an early high excess in morbidity and mortality but with low risk of additional adverse events in the long term. Late tamponade is as deadly as acute tamponade.
Authors: Wojciech Wańha; Rafał Januszek; Michalina Kołodziejczak; Łukasz Kuźma; Mateusz Tajstra; Tomasz Figatowski; Malwina Smolarek-Nicpoń; Monika Gruz-Kwapisz; Brunon Tomasiewicz; Jerzy Bartuś; Andrzej Łoś; Dariusz Jagielak; Tomasz Roleder; Adrian Włodarczak; Jan Kulczycki; Mariusz Kowalewski; Damian Hudziak; Paweł Stachowiak; Jarosław Gorący; Katarzyna Sierakowska; Krzysztof Reczuch; Miłosz Jaguszewski; Sławomir Dobrzycki; Grzegorz Smolka; Stanisław Bartuś; Andrzej Ochała; Mariusz Gąsior; Wojciech Wojakowski Journal: PLoS One Date: 2021-05-12 Impact factor: 3.240