Literature DB >> 3181375

The effect of a bradykinin antagonist on vasodilator responses with particular reference to the submandibular gland of the cat.

S Barton1, E Karpinski, M Schachter.   

Abstract

A bradykinin analogue, D-Arg[Hyp3, Thi5,8, D-Phe7]-Bk, antagonized the vasodilator effect of bradykinin injected close-arterially in the submandibular salivary gland of the cat, without affecting that due to acetylcholine or nerve stimulation. The same analogue also antagonized the hypotensive response to bradykinin injected intravenously in cats and rabbits. We conclude that functional hyperaemia in the submandibular gland of the cat is not due to the release of bradykinin by salivary kallikrein.

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Year:  1988        PMID： 3181375     DOI： 10.1007/bf01941194

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  The relationship between glandular activity, bradykinin formation and functional vasodilatation in the submandibular salivary gland.

Authors:  S M HILTON; G P LEWIS
Journal:  J Physiol       Date:  1956-11-28       Impact factor: 5.182

2.  New synthetic antagonists of bradykinin.

Authors:  M Schachter; Y Uchida; D J Longridge; T Labedz; E T Whalley; R J Vavrek; J M Stewart
Journal:  Br J Pharmacol       Date:  1987-12       Impact factor: 8.739

3.  Secretion of kallikrein and its role in vasodilatation in the submaxillary gland.

Authors:  S Beilenson; M Schachter; L H Smaje
Journal:  J Physiol       Date:  1968-12       Impact factor: 5.182

4.  Biological activities of kinins modified at the N- or at the C-terminal end.

Authors:  J N Drouin; P Gaudreau; S St-Pierre; D Regoli
Journal:  Can J Physiol Pharmacol       Date:  1979-09       Impact factor: 2.273

5.  Kallikrein-kinin system in regulation of submandibular gland blood flow.

Authors:  T B Orstavik; O A Carretero; A G Scicli
Journal:  Am J Physiol       Date:  1982-06

Review 6.  Pharmacology of bradykinin and related kinins.

Authors:  D Regoli; J Barabé
Journal:  Pharmacol Rev       Date:  1980-03       Impact factor: 25.468

7.  Effect of bradykinin antagonists on bradykinin-induced plasma extravasation, venoconstriction, prostaglandin E2 release, nociceptor stimulation and contraction of the iris sphincter muscle in the rabbit.

Authors:  T Griesbacher; F Lembeck
Journal:  Br J Pharmacol       Date:  1987-10       Impact factor: 8.739

8.  A study of vasoactive intestinal peptide and acetylcholine as possible mediators of vasodilatation in the cat submandibular gland.

Authors:  E Karpinski; S Barton; D Longridge; M Schachter
Journal:  Can J Physiol Pharmacol       Date:  1984-06       Impact factor: 2.273

9.  Competitive antagonists of bradykinin.

Authors:  R J Vavrek; J M Stewart
Journal:  Peptides       Date:  1985 Mar-Apr       Impact factor: 3.750

10.  The actions of kinin antagonists on B1 and B2 receptor systems.

Authors:  D Regoli; G Drapeau; P Rovero; S Dion; P D'Orléans-Juste; J Barabé
Journal:  Eur J Pharmacol       Date:  1986-04-09       Impact factor: 4.432
  10 in total

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