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Literature DB >> 3181373

Action and interaction of two alpha 1-adrenoceptor agonists, methoxamine and St 587, on the rabbit's blood pressure and EEG.

Abstract

In rabbits methoxamine reversed the vasopressor effect of St 587 and abolished the EEG synchronizing action of St 587. The interaction on the blood pressure could be ascribed either to the different chemical structures of St 587 and methoxamine or to partial agonistic properties of St 587. The interaction on the EEG appears to be more complex.

Entities: Chemical Species

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Year: 1988 PMID： 3181373 DOI： 10.1007/bf01941190

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

9 in total

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Authors: R R Ruffolo; B S Turowski; P N Patil
Journal: J Pharm Pharmacol Date: 1977-06 Impact factor: 3.765

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Authors: L GOLDSTEIN; C MUNOZ
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Authors: W B Pickworth; L G Sharpe; M Nozaki; W R Martin
Journal: Exp Neurol Date: 1977-12 Impact factor: 5.330

4. A lipophilic, selective alpha1 -adrenoceptor agonist: 2-(2-chloro-5-trifluoromethylphenylimino)imida-zolidine (St 587).

Authors: A D Jonge; J C van Meel; P B Timmermans; P A van Zwieten
Journal: Life Sci Date: 1981-05-04 Impact factor: 5.037

9. Synchronizing effect of the alpha 1-adrenoceptor agonist 2-(2-chloro-5-trifluoromethylphenylimino)imidazolidine on rabbit electroencephalogram.

Authors: C Stumpf; L Pichler
Journal: Arzneimittelforschung Date: 1988-06

9 in total

Action and interaction of two alpha 1-adrenoceptor agonists, methoxamine and St 587, on the rabbit's blood pressure and EEG.

1. Lack of cross-desensitization between structurally dissimilar alpha-adrenoceptor agonists.

2. Influence of adrenergic stimulant and blocking drugs on cerebral electrical activity in curarized animals.

3. Sleep suppression induced by intravenous and intraventricular infusions of methoxamine in the dog.

4. A lipophilic, selective alpha1 -adrenoceptor agonist: 2-(2-chloro-5-trifluoromethylphenylimino)imida-zolidine (St 587).

5. Clonidine binds to imidazole binding sites as well as alpha 2-adrenoceptors in the ventrolateral medulla.

6. Presynaptic activity of the imidazolidine derivative ST 587, a highly selective alpha 1-adrenoceptor agonist.

7. Investigation of the central and peripheral actions of clonidine and methoxamine using a new in vivo rat preparation.

8. Central cardiovascular effects of alpha adrenergic drugs: differences between catecholamines and imidazolines.

9. Synchronizing effect of the alpha 1-adrenoceptor agonist 2-(2-chloro-5-trifluoromethylphenylimino)imidazolidine on rabbit electroencephalogram.