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Literature DB >> 31813601

Glucose-Sensing Neurons Reciprocally Regulate Insulin and Glucagon.

Abstract

A recent paper by Oh et al. identified a single pair of neurons in the fruit fly brain that directly senses 'blood' glucose levels and reciprocally regulates the secretion of insulin and glucagon. This study provides insight into how the brain regulates the circulation and storage of glucose.

Entities: Chemical Disease Gene Species

Keywords: glucose sensing; homeostasis; neuropeptides

Mesh：

Substances：
Insulin
Glucagon
Glucose

Year: 2019 PMID： 31813601 PMCID： PMC6942241 DOI： 10.1016/j.tins.2019.11.006

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

Keyword Cloud
References

8 in total

1. Glucose increases activity and Ca2+ in insulin-producing cells of adult Drosophila.

Authors: Orsolya Kréneisz; Xinnian Chen; Yih-Woei C Fridell; Daniel K Mulkey
Journal: Neuroreport Date: 2010-12-08 Impact factor: 1.837

2. Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion.

Authors: Akhila Rajan; Norbert Perrimon
Journal: Cell Date: 2012-09-28 Impact factor: 41.582

3. Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila.

Authors: Xiao Zhao; Jason Karpac
Journal: Curr Biol Date: 2017-06-29 Impact factor: 10.834

4. Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin.

Authors: Neval Kapan; Oleh V Lushchak; Jiangnan Luo; Dick R Nässel
Journal: Cell Mol Life Sci Date: 2012-07-25 Impact factor: 9.261

Glucose-Sensing Neurons Reciprocally Regulate Insulin and Glucagon.

1. Glucose increases activity and Ca2+ in insulin-producing cells of adult Drosophila.

2. Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion.

3. Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila.

4. Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin.

5. Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila.

6. Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells.

7. A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila.

Review 8. Regulation of insulin and adipokinetic hormone/glucagon production in flies.