Literature DB >> 31813457

Oncohistone Mutations in Diffuse Intrinsic Pontine Glioma.

Xu Zhang1, Zhiguo Zhang2.   

Abstract

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric tumor with no currently available treatment options. More than 60-70% DIPG tumors harbor heterozygous mutations at genes encoding histone H3 proteins that replace lysine 27 with methionine (K27M). In this review, we discuss how K27M mutation reprograms the cancer epigenome to lead to tumorigenesis, and highlight potential drug targets and therapeutic agents for DIPG.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  H3K27M; diffuse intrinsic pontine glioma; oncohistone mutation; poised enhancers

Year:  2019        PMID： 31813457      PMCID： PMC6986369          DOI： 10.1016/j.trecan.2019.10.009

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  79 in total

1.  Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.

Authors:  Jeremy Schwartzentruber; Andrey Korshunov; Xiao-Yang Liu; David T W Jones; Elke Pfaff; Karine Jacob; Dominik Sturm; Adam M Fontebasso; Dong-Anh Khuong Quang; Martje Tönjes; Volker Hovestadt; Steffen Albrecht; Marcel Kool; Andre Nantel; Carolin Konermann; Anders Lindroth; Natalie Jäger; Tobias Rausch; Marina Ryzhova; Jan O Korbel; Thomas Hielscher; Peter Hauser; Miklos Garami; Almos Klekner; Laszlo Bognar; Martin Ebinger; Martin U Schuhmann; Wolfram Scheurlen; Arnulf Pekrun; Michael C Frühwald; Wolfgang Roggendorf; Christoph Kramm; Matthias Dürken; Jeffrey Atkinson; Pierre Lepage; Alexandre Montpetit; Magdalena Zakrzewska; Krzystof Zakrzewski; Pawel P Liberski; Zhifeng Dong; Peter Siegel; Andreas E Kulozik; Marc Zapatka; Abhijit Guha; David Malkin; Jörg Felsberg; Guido Reifenberger; Andreas von Deimling; Koichi Ichimura; V Peter Collins; Hendrik Witt; Till Milde; Olaf Witt; Cindy Zhang; Pedro Castelo-Branco; Peter Lichter; Damien Faury; Uri Tabori; Christoph Plass; Jacek Majewski; Stefan M Pfister; Nada Jabado
Journal:  Nature       Date:  2012-01-29       Impact factor: 49.962

2.  A bivalent chromatin structure marks key developmental genes in embryonic stem cells.

Authors:  Bradley E Bernstein; Tarjei S Mikkelsen; Xiaohui Xie; Michael Kamal; Dana J Huebert; James Cuff; Ben Fry; Alex Meissner; Marius Wernig; Kathrin Plath; Rudolf Jaenisch; Alexandre Wagschal; Robert Feil; Stuart L Schreiber; Eric S Lander
Journal:  Cell       Date:  2006-04-21       Impact factor: 41.582

3.  H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo.

Authors:  André B Silveira; Lawryn H Kasper; Yiping Fan; Hongjian Jin; Gang Wu; Timothy I Shaw; Xiaoyan Zhu; Jon D Larson; John Easton; Ying Shao; Donald A Yergeau; Celeste Rosencrance; Kristy Boggs; Michael C Rusch; Liang Ding; Junyuan Zhang; David Finkelstein; Rachel M Noyes; Brent L Russell; Beisi Xu; Alberto Broniscer; Cynthia Wetmore; Stanley B Pounds; David W Ellison; Jinghui Zhang; Suzanne J Baker
Journal:  Acta Neuropathol       Date:  2019-02-15       Impact factor: 17.088

4.  Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.

Authors:  Thomas Ernst; Andrew J Chase; Joannah Score; Claire E Hidalgo-Curtis; Catherine Bryant; Amy V Jones; Katherine Waghorn; Katerina Zoi; Fiona M Ross; Andreas Reiter; Andreas Hochhaus; Hans G Drexler; Andrew Duncombe; Francisco Cervantes; David Oscier; Jacqueline Boultwood; Francis H Grand; Nicholas C P Cross
Journal:  Nat Genet       Date:  2010-07-04       Impact factor: 38.330

5.  Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas.

Authors:  Daphne A Haas-Kogan; Anuradha Banerjee; Tina Young Poussaint; Mehmet Kocak; Michael D Prados; J Russell Geyer; Maryam Fouladi; Alberto Broniscer; Jane E Minturn; Ian F Pollack; Roger J Packer; James M Boyett; Larry E Kun
Journal:  Neuro Oncol       Date:  2011-03       Impact factor: 12.300

6.  SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.

Authors:  Ru Cao; Yi Zhang
Journal:  Mol Cell       Date:  2004-07-02       Impact factor: 17.970

7.  Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.

Authors:  Gang Wu; Alberto Broniscer; Troy A McEachron; Charles Lu; Barbara S Paugh; Jared Becksfort; Chunxu Qu; Li Ding; Robert Huether; Matthew Parker; Junyuan Zhang; Amar Gajjar; Michael A Dyer; Charles G Mullighan; Richard J Gilbertson; Elaine R Mardis; Richard K Wilson; James R Downing; David W Ellison; Jinghui Zhang; Suzanne J Baker
Journal:  Nat Genet       Date:  2012-01-29       Impact factor: 38.330

8.  Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome.

Authors:  Yasuhiro Arimura; Masae Ikura; Risa Fujita; Mamiko Noda; Wataru Kobayashi; Naoki Horikoshi; Jiying Sun; Lin Shi; Masayuki Kusakabe; Masahiko Harata; Yasuyuki Ohkawa; Satoshi Tashiro; Hiroshi Kimura; Tsuyoshi Ikura; Hitoshi Kurumizaka
Journal:  Nucleic Acids Res       Date:  2018-11-02       Impact factor: 16.971

9.  H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.

Authors:  Ashot S Harutyunyan; Brian Krug; Haifen Chen; Simon Papillon-Cavanagh; Michele Zeinieh; Nicolas De Jay; Shriya Deshmukh; Carol C L Chen; Jad Belle; Leonie G Mikael; Dylan M Marchione; Rui Li; Hamid Nikbakht; Bo Hu; Gael Cagnone; Warren A Cheung; Abdulshakour Mohammadnia; Denise Bechet; Damien Faury; Melissa K McConechy; Manav Pathania; Siddhant U Jain; Benjamin Ellezam; Alexander G Weil; Alexandre Montpetit; Paolo Salomoni; Tomi Pastinen; Chao Lu; Peter W Lewis; Benjamin A Garcia; Claudia L Kleinman; Nada Jabado; Jacek Majewski
Journal:  Nat Commun       Date:  2019-03-19       Impact factor: 14.919

10.  BMI-1 is a potential therapeutic target in diffuse intrinsic pontine glioma.

Authors:  Shiva Senthil Kumar; Satarupa Sengupta; Kyungwoo Lee; Nanki Hura; Christine Fuller; Mariko DeWire; Charles B Stevenson; Maryam Fouladi; Rachid Drissi
Journal:  Oncotarget       Date:  2017-05-19
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  3 in total

Review 1.  Asymmetric inheritance of epigenetic states in asymmetrically dividing stem cells.

Authors:  Emily H Zion; Chinmayi Chandrasekhara; Xin Chen
Journal:  Curr Opin Cell Biol       Date:  2020-08-29       Impact factor: 8.382

2.  LINC00467 facilitates the proliferation, migration and invasion of glioma via promoting the expression of inositol hexakisphosphate kinase 2 by binding to miR-339-3p.

Authors:  Yin Zhang; Yaxuan Zhang; Sen Wang; Boqiang Cao; Daling Hu; Junli Jia; Yuhang Wang; Luyao Chen; Jiaming Li; Hongyi Liu; Huamin Tang
Journal:  Bioengineered       Date:  2022-02       Impact factor: 6.832

3.  Targeting metabolic/epigenetic pathways: a potential strategy for cancer therapy in diffuse intrinsic pontine gliomas.

Authors:  Kun Zhao; Hongming Miao
Journal:  Signal Transduct Target Ther       Date:  2020-10-06
  3 in total

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