Literature DB >> 31813449

Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis?

Daniel Rosel1, Michael Fernandes2, Victoria Sanz-Moreno3, Jan Brábek4.   

Abstract

The concept of 'migrastatics' allows the development of a new drug class that is neither cytotoxic nor antiproliferative but is solely directed towards inhibition of cancer cell motility. Given that the regulatory pathway is open, and migrastatic candidates have been described, it is the right time to enter a new era of antimetastatic treatment.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  cancer therapy; invasiveness; metastasis; migrastatic treatment

Year:  2019        PMID： 31813449     DOI： 10.1016/j.trecan.2019.10.011

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  7 in total

Review 1.  Monitoring and modulation of the tumor microenvironment for enhanced cancer modeling.

Authors:  Tristen Head; Nathaniel C Cady
Journal:  Exp Biol Med (Maywood)       Date:  2022-01-28

2.  Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ.

Authors:  Zuodong Ye; Dawei Wang; Yingying Lu; Yunjiao He; Jingting Yu; Wenjie Wei; Chang Chen; Rui Wang; Liang Zhang; Liangren Zhang; Minh T N Le; William C Cho; Mengsu Yang; Hongmin Zhang; Jianbo Yue
Journal:  Oncogene       Date:  2021-02-09       Impact factor: 9.867

3.  Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma.

Authors:  Zihang Ling; Wei Li; Jiaqi Hu; Yuanyuan Li; Miao Deng; Siyuan Zhang; Xianyue Ren; Tong Wu; Juan Xia; Bin Cheng; Xiaoan Tao
Journal:  Cell Death Dis       Date:  2022-02-17       Impact factor: 8.469

4.  Complex Interplay of Genes Underlies Invasiveness in Fibrosarcoma Progression Model.

Authors:  Michaela Kripnerová; Hamendra Singh Parmar; Jiří Šána; Alena Kopková; Lenka Radová; Sieghart Sopper; Krzysztof Biernacki; Jan Jedlička; Michaela Kohoutová; Jitka Kuncová; Jan Peychl; Emil Rudolf; Miroslav Červinka; Zbyněk Houdek; Pavel Dvořák; Kateřina Houfková; Martin Pešta; Zdeněk Tůma; Martina Dolejšová; Filip Tichánek; Václav Babuška; Martin Leba; Ondřej Slabý; Jiří Hatina
Journal:  J Clin Med       Date:  2021-05-25       Impact factor: 4.241

Review 5.  Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19.

Authors:  Jan Brábek; Milan Jakubek; Fréderic Vellieux; Jiří Novotný; Michal Kolář; Lukáš Lacina; Pavol Szabo; Karolína Strnadová; Daniel Rösel; Barbora Dvořánková; Karel Smetana
Journal:  Int J Mol Sci       Date:  2020-10-26       Impact factor: 5.923

Review 6.  Mutational drivers of cancer cell migration and invasion.

Authors:  Nikita M Novikov; Sofia Y Zolotaryova; Alexis M Gautreau; Evgeny V Denisov
Journal:  Br J Cancer       Date:  2020-11-18       Impact factor: 7.640

7.  A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma.

Authors:  Oscar Maiques; Bruce Fanshawe; Eva Crosas-Molist; Irene Rodriguez-Hernandez; Alessia Volpe; Gaia Cantelli; Lena Boehme; Jose L Orgaz; Faraz K Mardakheh; Victoria Sanz-Moreno; Gilbert O Fruhwirth
Journal:  Br J Cancer       Date:  2021-06-25       Impact factor: 7.640
  7 in total

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