Dario Consonni1, Sara De Matteis2, Barbara Dallari3, Angela C Pesatori4, Luciano Riboldi5, Carolina Mensi6. 1. Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: dario.consonni@unimi.it. 2. National Heart & Lung Institute, Imperial College London, London, UK. Electronic address: s.de-matteis@imperial.ac.uk. 3. Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: barbaradallari@yahoo.it. 4. Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. Electronic address: angela.pesatori@unimi.it. 5. Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: luciano.riboldi@unimi.it. 6. Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: carolina.mensi@unimi.it.
Abstract
BACKGROUND: Broni is a small town (9000 inhabitants) in the province of Pavia, Lombardy, north-west Italy, where the second largest Italian asbestos cement factory (Fibronit) was in operation between 1932 and 1993. Based on Lombardy Mesothelioma Registry (RML) data (2000-2011), we previously showed a high impact of asbestos exposure on malignant mesothelioma (MM) incidence among Fibronit workers, their families, and people living in Broni and in the nearby town of Stradella (11,000 residents). Given the great concern of the community, we have recently updated the data regarding 5 more years (2012-2016). METHODS: From the RML database we extracted subjects who ever worked in Fibronit, their family members, ever residents in Broni, and subjects living in Stradella and nearby towns at the time of diagnosis. For each type of exposure we calculated standardized incidence ratios (SIR = observed/expected cases). RESULTS: In the period 2000-2016 we registered 56 cases (2.52 expected, SIR = 22.2), 49 men (41 pleural, 8 peritoneal MM), 7 women (5 pleural, 2 peritoneal MM) with past occupational exposure in Fibronit. Among subjects never occupationally exposed and never exposed to extra-occupational sources unrelated to Fibronit, we counted 39 cases (4.24 expected, SIR = 9.2), 10 men (all pleural MM), 29 women (28 pleural, 1 peritoneal MM) in Fibronit workers' families, 91 pleural mesothelioma cases (7.43 expected, SIR = 12.2, 31 men, 60 women), ever residents in Broni, and 25 pleural mesothelioma cases (3.05 expected, SIR = 8.2, 6 men, 19 women) living in Stradella at the time of diagnosis. The overall number of excess cases was about 194 (211 against 17.24 expected). In the remaining adjacent (No. 8) and surrounding (No. 17) municipalities (32,000 people) there were 7 cases (1 men, 6 women, 8.85 expected). CONCLUSION: The mesothelioma burden related to the asbestos cement factory is still high on factory workers, their families, and residents in Broni and Stradella towns.
BACKGROUND: Broni is a small town (9000 inhabitants) in the province of Pavia, Lombardy, north-west Italy, where the second largest Italian asbestos cement factory (Fibronit) was in operation between 1932 and 1993. Based on Lombardy Mesothelioma Registry (RML) data (2000-2011), we previously showed a high impact of asbestos exposure on malignant mesothelioma (MM) incidence among Fibronit workers, their families, and people living in Broni and in the nearby town of Stradella (11,000 residents). Given the great concern of the community, we have recently updated the data regarding 5 more years (2012-2016). METHODS: From the RML database we extracted subjects who ever worked in Fibronit, their family members, ever residents in Broni, and subjects living in Stradella and nearby towns at the time of diagnosis. For each type of exposure we calculated standardized incidence ratios (SIR = observed/expected cases). RESULTS: In the period 2000-2016 we registered 56 cases (2.52 expected, SIR = 22.2), 49 men (41 pleural, 8 peritoneal MM), 7 women (5 pleural, 2 peritoneal MM) with past occupational exposure in Fibronit. Among subjects never occupationally exposed and never exposed to extra-occupational sources unrelated to Fibronit, we counted 39 cases (4.24 expected, SIR = 9.2), 10 men (all pleural MM), 29 women (28 pleural, 1 peritoneal MM) in Fibronit workers' families, 91 pleural mesothelioma cases (7.43 expected, SIR = 12.2, 31 men, 60 women), ever residents in Broni, and 25 pleural mesothelioma cases (3.05 expected, SIR = 8.2, 6 men, 19 women) living in Stradella at the time of diagnosis. The overall number of excess cases was about 194 (211 against 17.24 expected). In the remaining adjacent (No. 8) and surrounding (No. 17) municipalities (32,000 people) there were 7 cases (1 men, 6 women, 8.85 expected). CONCLUSION: The mesothelioma burden related to the asbestos cement factory is still high on factory workers, their families, and residents in Broni and Stradella towns.
Authors: Leonardo Trivelli; Paola Borrelli; Ennio Cadum; Enrico Pisoni; Simona Villani Journal: Int J Environ Res Public Health Date: 2021-01-14 Impact factor: 3.390
Authors: Silvia Damiana Visonà; Silvana Capella; Sofia Bodini; Paola Borrelli; Simona Villani; Eleonora Crespi; Andrea Frontini; Claudio Colosio; Elena Belluso Journal: Int J Environ Res Public Health Date: 2021-02-19 Impact factor: 3.390
Authors: Laura Saracino; Chandra Bortolotto; Stefano Tomaselli; Elia Fraolini; Matteo Bosio; Giulia Accordino; Francesco Agustoni; David M Abbott; Emma Pozzi; Dimitrios Eleftheriou; Patrizia Morbini; Pietro Rinaldi; Cristiano Primiceri; Andrea Lancia; Patrizia Comoli; Andrea R Filippi; Giulia M Stella Journal: BMC Cancer Date: 2021-07-01 Impact factor: 4.430
Authors: Luigi Vimercati; Domenica Cavone; Maria Celeste Delfino; Antonio Caputi; Luigi De Maria; Stefania Sponselli; Vincenzo Corrado; Giovanni Maria Ferri; Gabriella Serio Journal: Int J Environ Res Public Health Date: 2020-04-12 Impact factor: 3.390
Authors: Andrea Spinazzè; Dario Consonni; Francesca Borghi; Sabrina Rovelli; Andrea Cattaneo; Carolina Zellino; Barbara Dallari; Angela Cecilia Pesatori; Hans Kromhout; Susan Peters; Luciano Riboldi; Domenico Maria Cavallo; Carolina Mensi Journal: Int J Environ Res Public Health Date: 2022-03-13 Impact factor: 3.390