Literature DB >> 3181188

Regional coupling of blood flow and methionine uptake in an experimental tumor assessed with autoradiography.

Y Abe1, T Matsuzawa, M Itoh, K Ishiwata, T Fujiwara, T Sato, K Yamaguchi, T Ido.   

Abstract

Regional distribution of L-[methyl-14C] methionine (14C-MET) and 4-[18F] fluoro-antipyrine was compared using experimental rat tumors (AH109A) and a computerized autoradiogram image processor. Tissue distributions of the two tracers were found to be inhomogeneous in the tumor with nearly identical image patterns. Analysis of tissue radioactivities revealed that 82% of 14C-MET was derived from the acid insoluble fraction at 60 min after injection. The present study showed that 14C-MET uptake closely relates to tissue blood flow and may depend on its blood to tissue transport. Rapid incorporation of MET in the acid insoluble fraction implies that it is rapidly metabolized after transport into tumor tissue.

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Year:  1988        PMID： 3181188     DOI： 10.1007/bf00254390

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  23 in total

1.  Distribution of anticancer agents in spontaneous animal tumors. I. Regional blood flow and methotrexate distribution in canine lymphosarcoma.

Authors:  J A Straw; M M Hart; P Klubes; D S Zaharko; R L Dedrick
Journal:  J Natl Cancer Inst       Date:  1974-04       Impact factor: 13.506

2.  Multiple-radionuclide autoradiography in evaluation of cerebral function.

Authors:  J L Lear; R Ackermann; M Kameyama; R Carson; M Phelps
Journal:  J Cereb Blood Flow Metab       Date:  1984-06       Impact factor: 6.200

3.  High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine.

Authors:  R M Hoffman; R W Erbe
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

4.  Labelling and metabolism of methionine-methyl-11 C.

Authors:  D Comar; J Cartron; M Maziere; C Marazano
Journal:  Eur J Nucl Med       Date:  1976

5.  Changes in tRNA methyltransferase activity and cellular S-adenosylmethionine content following methionine deprivation.

Authors:  M J Tisdale
Journal:  Biochim Biophys Acta       Date:  1980-09-19

6.  Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.

Authors:  K Ishiwata; T Ido; Y Abe; T Matsuzawa; M Murakami
Journal:  Eur J Nucl Med       Date:  1985

7.  Studies on the exchange of fluids between host and tumor. II. The blood flow of hepatomas and other tumors in rats and mice.

Authors:  P M GULLINO; F H GRANTHAM
Journal:  J Natl Cancer Inst       Date:  1961-12       Impact factor: 13.506

8.  Positron emission tomography with ([11C]methyl)-L-methionine, [11C]D-glucose, and [68Ga]EDTA in supratentorial tumors.

Authors:  K Ericson; A Lilja; M Bergström; V P Collins; L Eriksson; E Ehrin; H von Holst; H Lundqvist; B Långsrom B; M Mosskin
Journal:  J Comput Assist Tomogr       Date:  1985 Jul-Aug       Impact factor: 1.826

9.  Simultaneous measurement of blood flow and glucose metabolism by autoradiographic techniques.

Authors:  G Mies; I Niebuhr; K A Hossmann
Journal:  Stroke       Date:  1981 Sep-Oct       Impact factor: 7.914

10.  Effect of methionine deprivation on methylation and synthesis of macromolecules.

Authors:  M J Tisdale
Journal:  Br J Cancer       Date:  1980-07       Impact factor: 7.640
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  4 in total

1.  (14C-methyl)-L-methionine uptake in rat brain tumors before and after treatment with the protein synthesis inhibitor cycloheximide.

Authors:  K Mineura; T Sasajima; N Kuwahara; M Kowada; M Murakami; K Uemura
Journal:  J Neurooncol       Date:  1993-03       Impact factor: 4.130

2.  Uptake and distribution of L-3-[I-125] iodo-alpha-methyl tyrosine in experimental rat tumours: comparison with blood flow and growth rate.

Authors:  B Deehan; P Carnochan; M Trivedi; A Tombs
Journal:  Eur J Nucl Med       Date:  1993-02

3.  Uptake of 11C-methionine in breast cancer studied by PET. An association with the size of S-phase fraction.

Authors:  S Leskinen-Kallio; K Någren; P Lehikoinen; U Ruotsalainen; H Joensuu
Journal:  Br J Cancer       Date:  1991-12       Impact factor: 7.640

Review 4.  Biomarker selection and imaging design in cancer: A link with biochemical pathways for imminent engineering.

Authors:  Joham Surfraz Ali; Noor Ul Ain; Sania Naz; Muhammad Zia
Journal:  Heliyon       Date:  2020-02-03
  4 in total

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