DA-Hye Kim1, Song-I Han2, Boram Go3, Ui Hyeon Oh1, Chang-Sook Kim1, Yong-Hwan Jung3, Jungwhoi Lee4, Jae-Hoon Kim5,2. 1. Department of Biotechnology, College of Applied Life Science, Jeju National University, Jeju, Republic of Korea. 2. Subtropical/Tropical Organism Gene Bank, Jeju National University, Jeju, Republic of Korea. 3. Jeju Biodiversity Research Institute, Jeju Technopark, Jeju, Republic of Korea. 4. Subtropical/Tropical Organism Gene Bank, Jeju National University, Jeju, Republic of Korea kimjh@jejunu.ac.kr sdjd1108@kaist.ac.kr. 5. Department of Biotechnology, College of Applied Life Science, Jeju National University, Jeju, Republic of Korea kimjh@jejunu.ac.kr sdjd1108@kaist.ac.kr.
Abstract
BACKGROUND/AIM: No effective therapeutics have yet been developed for pancreatic cancer. 2-Methoxy-4-vinyl phenol (2M4VP), a member of the class of phenols, has been demonstrated to have anti-inflammatory properties and cause cell cycle arrest making it an attractive candidate drug for the treatment of pancreatic cancer. MATERIALS AND METHODS: The effects of 2M4VP were examined in Panc-1 and SNU-213 human pancreatic cancer cells. RESULTS: 2M4VP had anticancer effects on pancreatic cancer cell lines, Panc-1 and SNU-213. 2M4VP reduced the viability of Panc-1 cells by inhibiting the expression of the cell nuclear antigen (PCNA) protein. 2M4VP also suppressed the migratory activity of both cell lines. In addition, treatment with 2M4VP effectively decreased the phosphorylation of Focal Adhesion Kinase (FAK) and AKT. CONCLUSION: 2M4VP might be used as a pancreatic cancer treatment supplement. Copyright
BACKGROUND/AIM: No effective therapeutics have yet been developed for pancreatic cancer. 2-Methoxy-4-vinyl phenol (2M4VP), a member of the class of phenols, has been demonstrated to have anti-inflammatory properties and cause cell cycle arrest making it an attractive candidate drug for the treatment of pancreatic cancer. MATERIALS AND METHODS: The effects of 2M4VP were examined in Panc-1 and SNU-213 humanpancreatic cancer cells. RESULTS:2M4VP had anticancer effects on pancreatic cancer cell lines, Panc-1 and SNU-213. 2M4VP reduced the viability of Panc-1 cells by inhibiting the expression of the cell nuclear antigen (PCNA) protein. 2M4VP also suppressed the migratory activity of both cell lines. In addition, treatment with 2M4VP effectively decreased the phosphorylation of Focal Adhesion Kinase (FAK) and AKT. CONCLUSION:2M4VP might be used as a pancreatic cancer treatment supplement. Copyright
Authors: Baljinder Kaur; Rajan Rolta; Deeksha Salaria; Balvir Kumar; Olatomide A Fadare; Renato Araujo da Costa; Ajaz Ahmad; Mahmood Basil A Al-Rawi; Mohammad Raish; Irfan A Rather Journal: Molecules Date: 2022-06-24 Impact factor: 4.927