[Possible mechanism of the alteration in the therapeutic action of cyclophosphane in mice with hemocytoblastosis La against a background of artificial hyperglycemia].

The concentration of reactive cyclophosphamide metabolites (CP) and the time of their circulation in blood plasma of mice increase during artificial hyperglycemia (HG). Intensification of the antitumor CP activity against a background of HG in C57Bl/6 mice with hemocytoblastosis La may be a result of changes in the drug pharmacokinetics. An inhibitory action of HG on the CP-metabolizing system of the liver monooxygenases is shown.