Literature DB >> 31810049

Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization.

Henri De Greve1, Vikram Virdi2, Shruti Bakshi3, Ann Depicker4.   

Abstract

Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene encoded antibodies are much easier to manufacture and can be produced in plants and in yeast for bulk applications. These merits enable novel passive immunization applications, such as in-feed oral delivery of VHH-IgAs, which have successfully provided protection against a gastrointestinal infection in the piglet model.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2019        PMID： 31810049     DOI： 10.1016/j.copbio.2019.11.006

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  7 in total

1.  Biochemistry, structure, and cellular internalization of a four nanobody-bearing Fc dimer.

Authors:  Eric Chabrol; Charline Fagnen; Sophie Landron; Estelle Marcheteau; Johann Stojko; Sophie-Pénélope Guenin; Mathias Antoine; Benjamin Fould; Gilles Ferry; Jean A Boutin; Catherine Vénien-Bryan
Journal:  Protein Sci       Date:  2021-06-17       Impact factor: 6.993

2.  A Rationally Designed Bovine IgA Fc Scaffold Enhances in planta Accumulation of a VHH-Fc Fusion Without Compromising Binding to Enterohemorrhagic E. coli.

Authors:  Adam Chin-Fatt; Reza Saberianfar; Rima Menassa
Journal:  Front Plant Sci       Date:  2021-04-14       Impact factor: 5.753

3.  Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design.

Authors:  Alla Amcheslavsky; Aaron L Wallace; Monir Ejemel; Qi Li; Conor T McMahon; Matteo Stoppato; Serena Giuntini; Zachary A Schiller; Jessica R Pondish; Jacqueline R Toomey; Ryan M Schneider; Jordan Meisinger; Raimond Heukers; Andrew C Kruse; Eileen M Barry; Brian G Pierce; Mark S Klempner; Lisa A Cavacini; Yang Wang
Journal:  Sci Rep       Date:  2021-02-02       Impact factor: 4.379

4.  Development and characterization of a camelid derived antibody targeting a linear epitope in the hinge domain of human PCSK9 protein.

Authors:  Xinyang Li; Jun Hong; Xiaoyan Gao; Meiniang Wang; Naibo Yang
Journal:  Sci Rep       Date:  2022-07-16       Impact factor: 4.996

5.  Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants.

Authors:  Qi Li; Fiachra Humphries; Roxie C Girardin; Aaron Wallace; Monir Ejemel; Alla Amcheslavsky; Conor T McMahon; Zachary A Schiller; Zepei Ma; John Cruz; Alan P Dupuis; Anne F Payne; Arooma Maryam; Nese Kurt Yilmaz; Kathleen A McDonough; Brian G Pierce; Celia A Schiffer; Andrew C Kruse; Mark S Klempner; Lisa A Cavacini; Katherine A Fitzgerald; Yang Wang
Journal:  Front Immunol       Date:  2022-09-12       Impact factor: 8.786

Review 6.  Applications of nanobodies in plant science and biotechnology.

Authors:  Wenyi Wang; Jumao Yuan; Changan Jiang
Journal:  Plant Mol Biol       Date:  2020-10-10       Impact factor: 4.335

Review 7.  A guide to: generation and design of nanobodies.

Authors:  Serge Muyldermans
Journal:  FEBS J       Date:  2020-08-28       Impact factor: 5.542
  7 in total

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