Andreas Lundh1, Kristine Rasmussen2, Lasse Østengaard3, Isabelle Boutron4, Lesley A Stewart5, Asbjørn Hróbjartsson6. 1. Centre for Evidence-Based Medicine Odense (CEBMO), Odense University Hospital, Odense, Denmark; Open Patient data Exploratory Network (OPEN), Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Department of Infectious Diseases, Hvidovre Hospital, Hvidovre, Denmark. Electronic address: andreas.hover.lundh@rsyd.dk. 2. Cochrane Nordic, Rigshospitalet, Copenhagen, Denmark. 3. Centre for Evidence-Based Medicine Odense (CEBMO), Odense University Hospital, Odense, Denmark; Open Patient data Exploratory Network (OPEN), Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; University Library of Southern Denmark, Odense, Denmark. 4. Centre of Research in Epidemiology and StatisticS (CRESS), Inserm, INRA, Université de Paris, Paris, France. 5. Centre for Reviews and Dissemination, University of York, York, UK. 6. Centre for Evidence-Based Medicine Odense (CEBMO), Odense University Hospital, Odense, Denmark; Open Patient data Exploratory Network (OPEN), Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Abstract
OBJECTIVES: The objective of this study was to identify and summarize 1) appraisal tools and other guides which address conflicts of interest in medical research studies; and 2) top journals with policies on managing conflicts of interest in journal papers. STUDY DESIGN AND SETTING: We searched bibliographic databases, other sources, and websites of 30 top medical journals. Two authors selected documents and extracted data. RESULTS: We included 27 appraisal tools. None were designed specifically for addressing conflicts of interest and they included only 1-2 short items on conflicts of interest. We also included eight other types of guides. Of 27 appraisal tools, 23 addressed study funding, and 19 authors' conflicts of interest. Nine tools addressed availability of conflicts of interest information, 13 reported conflicts of interest, and five influence from conflicts of interest. Twelve of 30 top journals had conflicts of interest managing policies (beyond disclosure). One journal restricted nonresearch papers (e.g., editorials) to authors without financial conflicts of interest and ten only restricted under certain circumstances. CONCLUSION: Appraisal tools that address conflicts of interest typically do so superficially and rarely address how conflicts of interest may influence studies. Less than half of top medical journals have explicit policies on managing conflicts of interest.
OBJECTIVES: The objective of this study was to identify and summarize 1) appraisal tools and other guides which address conflicts of interest in medical research studies; and 2) top journals with policies on managing conflicts of interest in journal papers. STUDY DESIGN AND SETTING: We searched bibliographic databases, other sources, and websites of 30 top medical journals. Two authors selected documents and extracted data. RESULTS: We included 27 appraisal tools. None were designed specifically for addressing conflicts of interest and they included only 1-2 short items on conflicts of interest. We also included eight other types of guides. Of 27 appraisal tools, 23 addressed study funding, and 19 authors' conflicts of interest. Nine tools addressed availability of conflicts of interest information, 13 reported conflicts of interest, and five influence from conflicts of interest. Twelve of 30 top journals had conflicts of interest managing policies (beyond disclosure). One journal restricted nonresearch papers (e.g., editorials) to authors without financial conflicts of interest and ten only restricted under certain circumstances. CONCLUSION: Appraisal tools that address conflicts of interest typically do so superficially and rarely address how conflicts of interest may influence studies. Less than half of top medical journals have explicit policies on managing conflicts of interest.
Authors: Camilla Hansen Nejstgaard; Lisa Bero; Asbjørn Hróbjartsson; Anders W Jørgensen; Karsten Juhl Jørgensen; Mary Le; Andreas Lundh Journal: Cochrane Database Syst Rev Date: 2020-12-08
Authors: Camilla H Nejstgaard; Lisa Bero; Asbjørn Hróbjartsson; Anders W Jørgensen; Karsten J Jørgensen; Mary Le; Andreas Lundh Journal: BMJ Date: 2020-12-09
Authors: Lasse Østengaard; Andreas Lundh; Tine Tjørnhøj-Thomsen; Suhayb Abdi; Mustafe H A Gelle; Lesley A Stewart; Isabelle Boutron; Asbjørn Hróbjartsson Journal: BMJ Date: 2020-10-27