Literature DB >> 3180978

Protection against absolute-ethanol-induced gastric antral and corpus mucosal injury. A gross and histologic study.

S K Lo1, F W Leung, P H Guth.   

Abstract

The purpose of this study was to systematically assess 100% ethanol-induced gross and histologic injury of the antral and the corpus mucosa of the rat stomach and the effect of two protective agents, a prostaglandin analog and meciadanol (a flavenoid) on this injury. The gross antral injury was much more subtle than the corpus injury. Therefore, different scoring criteria were developed for the antrum. Surprisingly, however, the extent and severity of histologic injury was similar in both areas. Pretreatment with either meciadanol or 16,16-dimethyl prostaglandin E2 significantly protected against this injury in the antrum as well as in the corpus.

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Year:  1988        PMID： 3180978     DOI： 10.1007/bf01536995

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  16 in total

1.  Canine gastric acid secretion and blood flow measurement in hemorrhagic shock.

Authors:  S Shirazi; T M Mueller; B M Hardy
Journal:  Gastroenterology       Date:  1977-07       Impact factor: 22.682

2.  Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin.

Authors:  E R Lacy; S Ito
Journal:  Gastroenterology       Date:  1982-09       Impact factor: 22.682

3.  Morphology of rat gastric mucosal damage, defense, and restitution in the presence of luminal ethanol.

Authors:  S Ito; E R Lacy
Journal:  Gastroenterology       Date:  1985-01       Impact factor: 22.682

4.  Sucralfate protection of the gastric mucosa against ethanol-induced injury: a prostaglandin-mediated process?

Authors:  D Hollander; A Tarnawski; H Gergely; R D Zipser
Journal:  Scand J Gastroenterol Suppl       Date:  1984

5.  Hemorrhagic shock and acid gastric injury in the rat. Comparison of gross and histologic findings.

Authors:  M Itoh; G Paulsen; P H Guth
Journal:  Gastroenterology       Date:  1986-05       Impact factor: 22.682

6.  Changes of upper gastrointestinal blood flow after hemorrhage in rabbits.

Authors:  T Manabe; T Suzuki; I Honjo
Journal:  Surgery       Date:  1977-04       Impact factor: 3.982

7.  Effects of 16,16-dimethyl prostaglandin E2 on ethanol-induced and aspirin-induced gastric damage in the rat. Scanning electron microscopic study.

Authors:  T Ohno; H Ohtsuki; S Okabe
Journal:  Gastroenterology       Date:  1985-01       Impact factor: 22.682

8.  Evaluation of the protection of rat gastric mucosa by a prostaglandin analogue using cellular enzyme marker and histologic techniques.

Authors:  B J Whittle; G Steel
Journal:  Gastroenterology       Date:  1985-01       Impact factor: 22.682

9.  Role of blood flow in gastric and duodenal mucosal injury in the rat.

Authors:  F W Leung; M Itoh; K Hirabayashi; P H Guth
Journal:  Gastroenterology       Date:  1985-01       Impact factor: 22.682

10.  Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: effect of prostaglandin cytoprotection.

Authors:  P H Guth; G Paulsen; H Nagata
Journal:  Gastroenterology       Date:  1984-11       Impact factor: 22.682
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  10 in total

1.  Changes of gastric and intestinal blood flow, serum phospholipase A2 and interleukin-1beta in rats with acute necrotizing pancreatitis.

Authors:  Jian-Xin Zhang; Sheng-Chun Dang; Jian-Guo Qu; Xue-Qing Wang; Guo-Zuo Chen
Journal:  World J Gastroenterol       Date:  2005-06-21       Impact factor: 5.742

2.  Gastroprotective effect of intragastric clarithromycin against damage induced by ethanol in rats.

Authors:  C A Gutiérrez-Cabano; A C Raynald
Journal:  Dig Dis Sci       Date:  1999-08       Impact factor: 3.199

3.  Protection by intragastric polyethylene glycol 400 in rat stomach against ethanol damage involves alpha2-adrenoceptors.

Authors:  C A Gutiérrez-Cabano
Journal:  Dig Dis Sci       Date:  2000-01       Impact factor: 3.199

4.  Intragastric polyethylene glycol-400 protects against ethanol-induced gastric mucosal lesions despite pretreatment with indomethacin or iodoacetamide.

Authors:  C A Gutiérrez-Cabano
Journal:  Dig Dis Sci       Date:  1995-09       Impact factor: 3.199

5.  Involvement of alpha 2-adrenoceptors in mechanism of intragastric nicotine protection against ethanol injury in rat stomach.

Authors:  K Endoh; J Kao; M Baker; F W Leung
Journal:  Dig Dis Sci       Date:  1993-04       Impact factor: 3.199

6.  Mechanism of intragastric tetramethylammonium protection against 40% ethanol injury in rat stomach.

Authors:  K Endoh; J Kao; M Baker; O U Scremin; F W Leung
Journal:  Dig Dis Sci       Date:  1993-04       Impact factor: 3.199

7.  Intragastric nicotine protects against 40% ethanol-induced gastric injury despite pretreatment with NG-nitro-L-arginine methyl ester or adrenal medullectomy in rats.

Authors:  F Iwata; K Endoh; F W Leung
Journal:  Dig Dis Sci       Date:  1994-02       Impact factor: 3.199

8.  Mechanism of intragastric nicotine protection against ethanol-induced gastric injury.

Authors:  K Endoh; M Baker; F W Leung
Journal:  Dig Dis Sci       Date:  1991-01       Impact factor: 3.199

9.  Intragastric nicotine protects against 40% ethanol-induced gastric mucosal injury despite pretreatment with propranolol or N-ethylmaleimide in rats.

Authors:  K Endoh; G Ro; F W Leung
Journal:  Dig Dis Sci       Date:  1992-03       Impact factor: 3.199

10.  Intragastric nicotine protection against 40% ethanol injury in rat stomach. Role of ganglionic stimulation or blockade.

Authors:  K Endoh; J Kao; M Baker; F W Leung
Journal:  Dig Dis Sci       Date:  1992-12       Impact factor: 3.199
  10 in total

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