Background: Long noncoding RNA (lncRNA) GATA6-AS regulates the growth of endothelial cells, indicating its involvement in human diseases. The present study aimed to investigate the roles of GATA6-AS in glioma. Results: GATA6-AS was significantly upregulated in glioma. GATA6-AS levels in plasma was positively and significantly correlated with its expression levels in glioma tissues. TUG1 was significantly downregulated in glioma and was inversely correlated with GATA6-AS. GATA6-AS overexpression led to TUG1 downregulation, whereas TUG1 overexpression failed to significantly affect GATA6-AS. GATA6-AS overexpression promoted glioma cell proliferation and inhibited apoptosis, TUG1 overexpression inhibited cell proliferation and attenuated the effects of GATA6-AS overexpression. Conclusions: Therefore, lncRNA GATA6-AS affects cell proliferation and apoptosis and regulates TUG1 expression in glioma.
Background: Long noncoding RNA (lncRNA) GATA6-AS regulates the growth of endothelial cells, indicating its involvement in human diseases. The present study aimed to investigate the roles of GATA6-AS in glioma. Results:GATA6-AS was significantly upregulated in glioma. GATA6-AS levels in plasma was positively and significantly correlated with its expression levels in glioma tissues. TUG1 was significantly downregulated in glioma and was inversely correlated with GATA6-AS. GATA6-AS overexpression led to TUG1 downregulation, whereas TUG1 overexpression failed to significantly affect GATA6-AS. GATA6-AS overexpression promoted glioma cell proliferation and inhibited apoptosis, TUG1 overexpression inhibited cell proliferation and attenuated the effects of GATA6-AS overexpression. Conclusions: Therefore, lncRNA GATA6-AS affects cell proliferation and apoptosis and regulates TUG1 expression in glioma.
Authors: Mohamed Y Elwazir; Mohammad H Hussein; Eman A Toraih; Essam Al Ageeli; Safya E Esmaeel; Manal S Fawzy; Salwa Faisal Journal: Biomolecules Date: 2022-01-15