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Literature DB >> 31808778

A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status.

Yong Woong Jun¹, Marian Hebenbrock, Eric T Kool.

Abstract

Abnormal vitamin B6 status, marked by deficient intracellular concentrations of pyridoxal phosphate (PLP), is classified as a direct biomarker based on its biomedical significance. However, there exist no direct methods for measuring vitamin B6 status in intact cells. Here we describe the development of a fluorogenic probe, RAB6, which shows remarkable selectivity for PLP among the B6 vitamers and other cellular aldehydes.

Entities: CellLine Chemical Disease Gene Species

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Year: 2019 PMID： 31808778 PMCID： PMC7061904 DOI： 10.1039/c9cc08458d

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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References

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A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status.

Review 1. Vitamin B6 biosynthesis: charting the mechanistic landscape.

2. Selective fluorogenic and chromogenic probe for detection of silver ions and silver nanoparticles in aqueous media.

Review 3. Direct and Functional Biomarkers of Vitamin B6 Status.

Review 4. Hydrazone linkages in pH responsive drug delivery systems.

5. Ratiometric Imaging of Tissue by Two-Photon Microscopy: Observation of a High Level of Formaldehyde around Mouse Intestinal Crypts.

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