BACKGROUND: The high incidence of post-transplant diabetes mellitus (PTDM) necessitates the identification of new factors to explain its pathogenesis. This study aimed to clarify the association between the C-peptide index (CPI) and PTDM. METHODS: A total of 290 non-diabetic kidney transplant patients were analyzed. All subjects underwent a 75 g oral glucose tolerance test (OGTT). Plasma glucose concentrations, serum C-peptide levels, hemoglobin A1c (HbA1c), and other biochemical indicators were measured. CPI was calculated as the ratio of serum C-peptide to plasma glucose. RESULTS: Among the 290 patients, 36 (12.4%) developed PTDM at the end of 1 year. Patients with PTDM had older age (P<0.001), higher levels of body mass index (BMI) (P=0.004) and HbA1c (P=0.001), a higher proportion of deceased donors (P=0.045), and lower levels of 2 h-CPI (P=0.02) than those without PTDM. The OGTT 2 h-CPI was positively correlated with BMI, HbA1c, type of calcineurin inhibitor, albumin, and triglyceride. Multivariate logistic regression and Cox hazard model analysis showed that pre-transplant OGTT 2 h-CPI was an independent predictor for the development of PTDM, together with age, BMI, and HbA1c. CONCLUSIONS: Of the pre-transplant factors studied, OGTT 2 h-CPI proved to be an independent predictor of PTDM. 2019 Annals of Translational Medicine. All rights reserved.
BACKGROUND: The high incidence of post-transplant diabetes mellitus (PTDM) necessitates the identification of new factors to explain its pathogenesis. This study aimed to clarify the association between the C-peptide index (CPI) and PTDM. METHODS: A total of 290 non-diabetic kidney transplant patients were analyzed. All subjects underwent a 75 g oral glucose tolerance test (OGTT). Plasma glucose concentrations, serum C-peptide levels, hemoglobin A1c (HbA1c), and other biochemical indicators were measured. CPI was calculated as the ratio of serum C-peptide to plasma glucose. RESULTS: Among the 290 patients, 36 (12.4%) developed PTDM at the end of 1 year. Patients with PTDM had older age (P<0.001), higher levels of body mass index (BMI) (P=0.004) and HbA1c (P=0.001), a higher proportion of deceased donors (P=0.045), and lower levels of 2 h-CPI (P=0.02) than those without PTDM. The OGTT 2 h-CPI was positively correlated with BMI, HbA1c, type of calcineurin inhibitor, albumin, and triglyceride. Multivariate logistic regression and Cox hazard model analysis showed that pre-transplant OGTT 2 h-CPI was an independent predictor for the development of PTDM, together with age, BMI, and HbA1c. CONCLUSIONS: Of the pre-transplant factors studied, OGTT 2 h-CPI proved to be an independent predictor of PTDM. 2019 Annals of Translational Medicine. All rights reserved.
Authors: Motoo Araki; Stuart M Flechner; Hazem R Ismail; Lawrence M Flechner; Lingmei Zhou; Ithaar H Derweesh; David Goldfarb; Charles Modlin; Andrew C Novick; Charles Faiman Journal: Transplantation Date: 2006-02-15 Impact factor: 4.939
Authors: E Ishimura; S Okuno; K Kono; Y Fujino-Kato; Y Maeno; S Kagitani; N Tsuboniwa; K Nagasue; K Maekawa; T Yamakawa; M Inaba; Y Nishizawa Journal: Diabetes Res Clin Pract Date: 2009-01-09 Impact factor: 5.602
Authors: Juris J Meier; Bjoern A Menge; Thomas G K Breuer; Christophe A Müller; Andrea Tannapfel; Waldemar Uhl; Wolfgang E Schmidt; Henning Schrader Journal: Diabetes Date: 2009-06-09 Impact factor: 9.461