Literature DB >> 31807353

Combination of mineral trioxide aggregate and propolis promotes odontoblastic differentiation of human dental pulp stem cells through ERK signaling pathway.

Jae-Hwan Kim1, Soo-Yung Kim1, Su-Mi Woo2, Ha-Na Jeong3, Ji-Yeon Jung2, Seon-Mi Kim1, Hae-Soon Lim3,4.   

Abstract

The aim of this study is to investigate combined effects of mineral trioxide aggregate (MTA) and propolis on odontoblastic differentiation of human dental pulp stem cells (DPSCs) and to find a signaling pathway involved. Combination of MTA and propolis significantly up-regulated the expression of DSPP and DMP1, and facilitated a mineral nodule formation (p < 0.05). Treatments with MTA, propolis or combined increased the phosphorylation of extracellular signal-regulated kinases (ERK), one of mitogen-activated protein kinases signaling cascades during odontogenic differentiation of DPSCs (p < 0.05), and U0126, an inhibitor of ERK, decreased calcium deposits (p < 0.05). Combination of MTA and propolis promotes odontogenic differentiation and mineralization of DPSCs through ERK pathway. © The Korean Society of Food Science and Technology 2019.

Entities:  

Keywords:  ERK signaling; Human dental pulp cells; Mineral trioxide aggregate; Odontoblastic differentiation; Propolis

Year:  2019        PMID： 31807353      PMCID： PMC6859184          DOI： 10.1007/s10068-019-00609-5

Source DB:  PubMed          Journal:  Food Sci Biotechnol        ISSN： 1226-7708            Impact factor:   2.391


  41 in total

1.  Screening of antibacterial activity of Amaicha del Valle (Tucumán, Argentina) propolis.

Authors:  M I Nieva Moreno; M I Isla; N G Cudmani; M A Vattuone; A R Sampietro
Journal:  J Ethnopharmacol       Date:  1999-12-15       Impact factor: 4.360

2.  Stem cell properties of human dental pulp stem cells.

Authors:  S Gronthos; J Brahim; W Li; L W Fisher; N Cherman; A Boyde; P DenBesten; P Gehron Robey; S Shi
Journal:  J Dent Res       Date:  2002-08       Impact factor: 6.116

3.  Effect of isolation methodology on stem cell properties and multilineage differentiation potential of human dental pulp stem cells.

Authors:  P Hilkens; P Gervois; Y Fanton; J Vanormelingen; W Martens; T Struys; C Politis; I Lambrichts; A Bronckaers
Journal:  Cell Tissue Res       Date:  2013-05-29       Impact factor: 5.249

4.  Preliminary report on the effects of propolis on wound healing in the dental pulp.

Authors:  W A Bretz; D J Chiego; M C Marcucci; I Cunha; A Custódio; L G Schneider
Journal:  Z Naturforsch C J Biosci       Date:  1998 Nov-Dec

5.  Differentiation of pulpal cells and inductive influences of various matrices with reference to pulpal wound healing.

Authors:  T Yamamura
Journal:  J Dent Res       Date:  1985-04       Impact factor: 6.116

6.  The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development.

Authors:  J Q Feng; H Huang; Y Lu; L Ye; Y Xie; T W Tsutsui; T Kunieda; T Castranio; G Scott; L B Bonewald; Y Mishina
Journal:  J Dent Res       Date:  2003-10       Impact factor: 6.116

7.  Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium.

Authors:  K E Schwab; C E Gargett
Journal:  Hum Reprod       Date:  2007-09-14       Impact factor: 6.918

8.  Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate-chitosan composite scaffold.

Authors:  Jennifer L Moreau; Hockin H K Xu
Journal:  Biomaterials       Date:  2009-02-01       Impact factor: 12.479

9.  In situ hybridization shows Dmp1 (AG1) to be a developmentally regulated dentin-specific protein produced by mature odontoblasts.

Authors:  A George; R Silberstein; A Veis
Journal:  Connect Tissue Res       Date:  1995       Impact factor: 3.417

10.  A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats.

Authors:  Hulya Toker; Fatih Ozan; Hatice Ozer; Hakan Ozdemir; Kaya Eren; Hasan Yeler
Journal:  J Periodontol       Date:  2008-06       Impact factor: 6.993
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  4 in total

1.  Comparative chemical properties, bioactivity, and cytotoxicity of resin-modified calcium silicate-based pulp capping materials on human dental pulp stem cells.

Authors:  Cihan Küden; Seda Nur Karakaş; Sevde Gül Batmaz
Journal:  Clin Oral Investig       Date:  2022-09-15       Impact factor: 3.606

2.  Bioinductive and anti-inflammatory properties of Propolis and Biodentine on SHED.

Authors:  Yogesh Kale; Swapnil Yadav; Mahesh Dadpe; Prasanna Dahake; Shrikant Kendre
Journal:  Saudi Dent J       Date:  2022-08-28

Review 3.  In vitro biocompatibility and bioactivity of calcium silicate‑based bioceramics in endodontics (Review).

Authors:  Wencheng Song; Shue Li; Qingming Tang; Lili Chen; Zhenglin Yuan
Journal:  Int J Mol Med       Date:  2021-05-20       Impact factor: 4.101

Review 4.  Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia.

Authors:  Fengxuan Han; Jiayuan Wang; Luguang Ding; Yuanbin Hu; Wenquan Li; Zhangqin Yuan; Qianping Guo; Caihong Zhu; Li Yu; Huan Wang; Zhongliang Zhao; Luanluan Jia; Jiaying Li; Yingkang Yu; Weidong Zhang; Genglei Chu; Song Chen; Bin Li
Journal:  Front Bioeng Biotechnol       Date:  2020-03-24
  4 in total

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