Literature DB >> 3180544

HLA antigens and clinical manifestations in Crohn's disease.

V Modena1, A Amoroso, C Frattasio, A Pera, P Costantini, I Maiocco, V Ponti, C C Di Vittorio, G Verme, E S Curtoni.   

Abstract

A clinical, radiological and immunogenetical study was carried out on 51 Crohn's patients. Rheumatological disorders were found in 16 of them, with higher frequency in those with colon involvement only. A statistically significant increase in the frequencies of HLA-A9 and HLA-Cw3 was noted: Cw3 showed a particularly high frequency in males, and A9 in younger patients. The frequency of HLA-B27 was significantly increased in the patients with colon involvement. In the group of 16 patients with rheumatic diseases HLA antigen frequencies were not significantly different from the control population.

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Year:  1988        PMID: 3180544

Source DB:  PubMed          Journal:  Clin Exp Rheumatol        ISSN: 0392-856X            Impact factor:   4.473


  3 in total

1.  HLA class II genes in primary sclerosing cholangitis and chronic inflammatory bowel disease: no HLA-DRw52a association in Swedish patients with sclerosing cholangitis.

Authors:  H Zetterquist; U Broomé; K Einarsson; O Olerup
Journal:  Gut       Date:  1992-07       Impact factor: 23.059

2.  Relationship between site of disease and familial occurrence in Crohn's disease.

Authors:  M Cottone; C Brignola; M Rosselli; L Oliva; C Belloli; C Cipolla; A Orlando; G De Simone; M R Aiala; R Di Mitri; G Gatto; A Buccellato
Journal:  Dig Dis Sci       Date:  1997-01       Impact factor: 3.199

3.  Crohn's disease: the genetic contribution.

Authors:  J Sofaer
Journal:  Gut       Date:  1993-07       Impact factor: 23.059

  3 in total

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