Marcello Scala1, Pietro Fiaschi2, Armando Cama3, Alessandro Consales3, Gianluca Piatelli3, Flavio Giannelli4, Salvina Barra4, Camilla Satragno5, Mattia Pacetti3, Francesca Secci3, Domenico Tortora6, Maria Luisa Garrè7, Marco Pavanello3. 1. Department of Neurosurgery, IRCCS Istituto Giannina Gaslini, Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy. Electronic address: marcelloscala87@gmail.com. 2. Division of Neurosurgery, Department of Neuroscience (DINOGMI), Ospedale Policlinico San Martino-IST, University of Genoa, Genoa. 3. Department of Neurosurgery, IRCCS Istituto Giannina Gaslini, Genoa, Italy. 4. Department of Radiation Oncology, Ospedale Policlinico San Martino, Genoa, Italy. 5. Health Science Department (DISSAL) and Radiation Oncology, Ospedale Policlinico San Martino, University of Genoa, Genoa and San Martino Hospital, Genoa, Italy. 6. Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy. 7. Neuroncology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Abstract
BACKGROUND: Over the last decades, significant advancements have been achieved in the treatment of pediatric brain tumors as a result of radiation therapy (RT). With the increasing diffusion of this treatment, iatrogenic damage to cerebrovascular tissues contouring the radiation target volume has become the subject of debate, especially radiation-induced moyamoya syndrome (RIMS). METHODS: A systematic literature search was performed on the association between moyamoya vasculopathy and cranial irradiation in children. Large case series of patients with moyamoya were analyzed and clinicoradiologic data were collected reviewing pediatric patients treated with RT for primary brain tumors at our institution. RESULTS: The risk of developing RIMS is higher in younger children, in patients with optic pathway glioma, and in those receiving higher radiation doses. Headache is the most common presenting symptom and cerebral infarction is frequent. The preferred surgical techniques were pial synangiosis and encephaloduroarteriosynangiosis. In our case series, surgical revascularization led to neovascularization, with clinical improvement or stability in all patients. Medical therapy did not significantly affect the clinical course. CONCLUSIONS: Pediatric patients receiving involved field RT for the treatment of brain tumors have an increased risk of developing RIMS. Prompt diagnosis and early surgical revascularization play a pivotal role in decreasing the clinical impact of this complication. The use of new techniques, such as the intensity-modulated RT, and the increasing dose saving for the organs at risk, are essential to prevent iatrogenic vasculopathy. The combination of appropriate medical therapy and surgery will improve patient management and clinical outcome.
BACKGROUND: Over the last decades, significant advancements have been achieved in the treatment of pediatric brain tumors as a result of radiation therapy (RT). With the increasing diffusion of this treatment, iatrogenic damage to cerebrovascular tissues contouring the radiation target volume has become the subject of debate, especially radiation-induced moyamoya syndrome (RIMS). METHODS: A systematic literature search was performed on the association between moyamoya vasculopathy and cranial irradiation in children. Large case series of patients with moyamoya were analyzed and clinicoradiologic data were collected reviewing pediatric patients treated with RT for primary brain tumors at our institution. RESULTS: The risk of developing RIMS is higher in younger children, in patients with optic pathway glioma, and in those receiving higher radiation doses. Headache is the most common presenting symptom and cerebral infarction is frequent. The preferred surgical techniques were pial synangiosis and encephaloduroarteriosynangiosis. In our case series, surgical revascularization led to neovascularization, with clinical improvement or stability in all patients. Medical therapy did not significantly affect the clinical course. CONCLUSIONS: Pediatric patients receiving involved field RT for the treatment of brain tumors have an increased risk of developing RIMS. Prompt diagnosis and early surgical revascularization play a pivotal role in decreasing the clinical impact of this complication. The use of new techniques, such as the intensity-modulated RT, and the increasing dose saving for the organs at risk, are essential to prevent iatrogenic vasculopathy. The combination of appropriate medical therapy and surgery will improve patient management and clinical outcome.
Authors: Francesca Vitulli; Pietro Spennato; Domenico Cicala; Giuseppe Mirone; Maria Rosaria Scala; Giuseppe Cinalli Journal: Surg Neurol Int Date: 2022-07-15