Literature DB >> 31805257

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.

Dylan Kwart, Andrew Gregg, Claudia Scheckel, Elisabeth A Murphy, Dominik Paquet, Michael Duffield, John Fak, Olav Olsen, Robert B Darnell, Marc Tessier-Lavigne.   

Abstract

Entities:  

Year:  2019        PMID： 31805257     DOI： 10.1016/j.neuron.2019.11.010

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


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  18 in total

1.  The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue.

Authors:  Derek H Oakley; Mirra Chung; Naomi Klickstein; Caitlin Commins; Bradley T Hyman; Matthew P Frosch
Journal:  J Neuropathol Exp Neurol       Date:  2020-06-01       Impact factor: 3.685

Review 2.  Defective Lysosomal Lipid Catabolism as a Common Pathogenic Mechanism for Dementia.

Authors:  Jun Yup Lee; Oana C Marian; Anthony S Don
Journal:  Neuromolecular Med       Date:  2021-02-07       Impact factor: 3.843

Review 3.  Leveraging preclinical models for the development of Alzheimer disease therapeutics.

Authors:  Kimberly Scearce-Levie; Pascal E Sanchez; Joseph W Lewcock
Journal:  Nat Rev Drug Discov       Date:  2020-04-08       Impact factor: 84.694

4.  Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model.

Authors:  Mariko Sawa; Cassia Overk; Ann Becker; Dominique Derse; Ricardo Albay; Kim Weldy; Ahmad Salehi; Thomas G Beach; Eric Doran; Elizabeth Head; Y Eugene Yu; William C Mobley
Journal:  Alzheimers Dement       Date:  2021-11-10       Impact factor: 16.655

5.  Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons.

Authors:  Masato Maesako; Mei C Q Houser; Yuliia Turchyna; Michael S Wolfe; Oksana Berezovska
Journal:  J Neurosci       Date:  2021-11-22       Impact factor: 6.709

6.  Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.

Authors:  Timothy J Hark; Nalini R Rao; Charlotte Castillon; Tamara Basta; Samuel Smukowski; Huan Bao; Arun Upadhyay; Ewa Bomba-Warczak; Toshihiro Nomura; Eileen T O'Toole; Garry P Morgan; Laith Ali; Takashi Saito; Christelle Guillermier; Takaomi C Saido; Matthew L Steinhauser; Michael H B Stowell; Edwin R Chapman; Anis Contractor; Jeffrey N Savas
Journal:  Cell Syst       Date:  2020-12-15       Impact factor: 10.304

Review 7.  Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?

Authors:  Frédéric Checler; Elissa Afram; Raphaëlle Pardossi-Piquard; Inger Lauritzen
Journal:  J Biol Chem       Date:  2021-03-01       Impact factor: 5.157

Review 8.  CRISPR-based functional genomics for neurological disease.

Authors:  Martin Kampmann
Journal:  Nat Rev Neurol       Date:  2020-07-08       Impact factor: 42.937

9.  Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes.

Authors:  Raja Bhattacharyya; Sophia E Black; Madhura S Lotlikar; Rebecca H Fenn; Mehdi Jorfi; Dora M Kovacs; Rudolph E Tanzi
Journal:  Cell Rep       Date:  2021-05-18       Impact factor: 9.423

10.  Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout.

Authors:  Charles Arber; Claudio Villegas-Llerena; Jamie Toombs; Jennifer M Pocock; Natalie S Ryan; Nick C Fox; Henrik Zetterberg; John Hardy; Selina Wray
Journal:  Brain Commun       Date:  2019-10-14
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