Literature DB >> 3180487

Stabilization and quantitative determination of disulfiram in human plasma samples.

B Johansson1.   

Abstract

The rapid reduction of disulfiram at therapeutic plasma concentrations was inhibited by addition of the chelating agent, diethylenetriamine pentaacetic acid, and acidification in the presence of sodium chloride. The disulfiram recovery at concentrations ranging from 0.100-0.800 mumol/l was about 100% when preserved at 4 degrees C and analyzed immediately, and 95% and 75% after preservation for 1 h at 4 degrees C and for 24 h at -20 degrees C, respectively. The concentrations of disulfiram were determined in plasma from alcoholics receiving repeated therapeutic doses of disulfiram. Detectable concentrations in the range of 0.100-0.200 mumol/l could not be obtained until the second week of treatment.

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Year:  1988        PMID： 3180487     DOI： 10.1016/0009-8981(88)90307-5

Source DB:  PubMed          Journal:  Clin Chim Acta        ISSN： 0009-8981            Impact factor:   3.786


  4 in total

1.  Disulfiram metabolite S-methyl-N,N-diethylthiocarbamate quantitation in human plasma with reverse phase ultra performance liquid chromatography and mass spectrometry.

Authors:  Jill Hochreiter; Elinore F McCance-Katz; Jill Lapham; Qing Ma; Gene D Morse
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2012-04-01       Impact factor: 3.205

2.  A Smart Paclitaxel-Disulfiram Nanococrystals for Efficient MDR Reversal and Enhanced Apoptosis.

Authors:  Imran Shair Mohammad; Wei He; Lifang Yin
Journal:  Pharm Res       Date:  2018-02-27       Impact factor: 4.200

3.  Translational balancing questioned: Unaltered glycosylation during disulfiram treatment in mannosyl-oligosaccharide alpha-1,2-mannnosidase-congenital disorders of glycosylation (MAN1B1-CDG).

Authors:  Lisa Kemme; Marianne Grüneberg; Janine Reunert; Stephan Rust; Julien Park; Cordula Westermann; Yoshinao Wada; Oliver Schwartz; Thorsten Marquardt
Journal:  JIMD Rep       Date:  2021-03-20

4.  Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells.

Authors:  Xinwei Liu; Lihui Wang; Wei Cui; Xiangzhong Yuan; Lulu Lin; Qi Cao; Nannan Wang; Yi Li; Wei Guo; Xun Zhang; Chunfu Wu; Jingyu Yang
Journal:  Oncotarget       Date:  2016-09-06
  4 in total

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