| Literature DB >> 31804615 |
Ido Livneh1, Sharon Moshitch-Moshkovitz2,3,4, Ninette Amariglio3,4,5, Gideon Rechavi2,3,4, Dan Dominissini6,7,8.
Abstract
The field of epitranscriptomics examines the recently deciphered form of gene expression regulation that is mediated by type- and site-specific RNA modifications. Similarly to the role played by epigenetic mechanisms - which operate via DNA and histone modifications - epitranscriptomic modifications are involved in the control of the delicate gene expression patterns that are needed for the development and activity of the nervous system and are essential for basic and higher brain functions. Here we describe the mechanisms that are involved in the writing, erasing and reading of N6-methyladenosine, the most prevalent internal mRNA modification, and the emerging roles played by N6-methyladenosine in the nervous system.Entities:
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Year: 2019 PMID： 31804615 DOI： 10.1038/s41583-019-0244-z
Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870