Incidence, Characteristics and Atherosclerotic Involvement of Coronary Artery Anomalies in Adult Population Undergoing Catheter Coronary Angiography.

BACKGROUND: Coronary artery anomalies (CAAs) are rare disorders of coronary anatomy with varied clinical presentations. There are widespread geographic variations in incidence and patterns of these anomalies, with limited data from North Indian population. We performed a retrospective study to evaluate the incidence, characteristics and atherosclerotic involvement of CAAs in adult population undergoing catheter coronary angiography.
METHODS: Serial coronary angiographies performed at our institution over a period of 2.5 years (from January 2017 to June 2019) were retrospectively analyzed. We identified patients with anomalous coronaries and studied their clinical characteristics and angiographic profiles.
RESULTS: Among 3,233 coronary angiograms analyzed, CAAs were found in 99 patients with an incidence of 3.06%. Mean age of the patients was 56.2 ± 12.9 years (range: 20 - 86 years), with 74.75% being males and 25.25% females. Split right coronary artery (RCA) was the most common coronary anomaly, being seen in 27 patients; with an angiographic incidence of 0.84%. Dual left anterior descending artery (LAD) was the second most common anomaly and was seen in 22 cases with an angiographic incidence of 0.68%. Absent left main trunk was noted in 14 patients (0.43%). Ectopic origin of RCA from left sinus was seen in 12 patients (0.37%), while ectopic origin of RCA from ascending aorta was seen in four patients (0.12%). Ectopic origin of left circumflex artery (LCX) from right sinus or RCA was noted in 13 patients (0.40%). One patient (0.03%) had a superdominant LAD supplying the posterior descending artery (PDA). Coronary artery fistulae were seen in six patients (0.18%). Significant coronary artery disease (CAD) was seen in 89 of 268 (33.21%) normal vessels, whereas it was seen in 56 of 114 (49.12%) of anomalous vessels. This difference was statistically significant (P = 0.003).
CONCLUSIONS: The incidence of CAAs in our study was slightly higher than many of the previous angiographic series. The patterns of coronary anomalies in our study were different from most of the previous studies. Our study had higher incidence of atherosclerotic involvement of anomalous vessels as compared to normal vessels. Copyright 2019, Sidhu et al.

Introduction

Coronary artery anomalies (CAAs) are a relatively uncommon, diverse group of congenital disorders of coronary arterial anatomy with a wide variety of clinical presentations. Though most commonly detected incidentally during coronary angiography or at autopsy, these anomalies have generated considerable interest as they constitute the second most common cause of sudden cardiac death in young competitive athletes after hypertrophic cardiomyopathy [1]. Although benign in majority of cases, about one-fifth of coronary anomalies may lead to life-threatening manifestations such as arrhythmias, syncope, sudden death or myocardial infarction [2, 3].

Presence of a coronary anomaly should be suspected in a young individual who experiences exertional syncope, exercise ­induced arrhythmias, myocardial infarction, or cardiac arrest.

Incidence of CAAs has been reported to be 0.6% to 5.64% in angiographic series and 0.3% in autopsy series [2-13]. In the absence of a unifying scientific statement/guidelines from any of major cardiovascular societies regarding definition, nomenclature and classification system of coronary anomalies, many such nomenclatures and classifications have been proposed from time to time [14-20]. Nomenclature and classification pattern proposed by Angelini and coworkers has been the most widely accepted system of classification [10, 19, 21, 22]. They proposed the following definition of coronary artery patterns: 1) Normal: any morphological pattern seen in > 1% of an unselected general population; 2) Normal variant: an alternative, relatively uncommon morphological pattern seen in > 1% of the same population; 3) Anomaly: a morphological pattern seen in < 1% of the same population.

Atherosclerotic involvement of anomalous coronaries as compared to normal coronaries is also a subject of active research with few studies showing increased susceptibility of anomalous coronaries to atherosclerosis as compared to normal coronaries [23, 24].

Performing coronary angiography in patients with CAAs can be challenging with increased fluoroscopic times. The operator should be able to accurately identify the anomaly and perform adequate evaluation in order to avoid errors in management of the patient. The cardiac surgeon must be aware of the anomalous anatomy so that inadvertent injuries like ligation or transection can be avoided during surgery.

There are widespread geographic variations in incidence and patterns of CAAs. There are limited data on CAAs from India especially on Punjabi population of North India. This study was planned to estimate the incidence, patterns and atherosclerotic involvement of anomalous coronaries in patients undergoing invasive coronary angiography at our tertiary care institution.

Materials and Methods

This retrospective descriptive study was conducted at the Department of Cardiology, GGS Medical College and Hospital, Faridkot, Punjab, India. Ours is a tertiary care referral institute with fully equipped cardiac catheterization laboratory. The study protocol was approved by our Institutional Review Board, and the study was conducted in accordance with the Declaration of Helsinki. A total of 3,233 coronary angiograms performed at our institution during a period of 2.5 years (from January 2017 to June 2019) were reviewed independently by two experienced invasive cardiologists for the presence of CAAs according to following criteria.

Inclusion criteria

Adult patients more than 18 years of age who underwent coronary angiography (CAG) for various indications like ischemic heart disease (IHD), left ventricular (LV) dysfunction or valvular heart disease etc. were included in this study.

Exclusion criteria

1) Patients with congenital heart diseases were excluded from the study population; 2) Patients with separate origin of the conus branch from the right coronary sinus (RCS); 3) Patients with origin of right ventricular branch from the RCS; 4) Patients with other coronary anomalies like coronary ectasia, myocardial bridging, and abnormal high and low origin of coronary arteries from normal sinus.

In case of any difference of opinion between the two reviewers, a consensus was reached after mutual discussion. The course of anomalous artery was determined according to methods described by Yamanaka and Hobbs and the “dot and eye” method [2, 25].The coronary anomalies were classified primarily based on classification system proposed by Angelini and coworkers (Table 1 [22]).

Table 1

Angelini Classification System for Coronary Anomalies

Anomalies of origin and course

Absent left main trunk

Anomalous location of coronary ostium within aortic root or adjacent to proper aortic sinus

Anomalous location of coronary ostium outside normal coronary sinuses

Anomalous location of coronary ostium at improper sinus

Single coronary artery

Anomalies of intrinsic coronary arterial anatomy

Congenital ostial stenosis or atresia

Coronary ostial dimple

Coronary ectasia or aneurysm

Absent coronary artery

Coronary hypoplasia

Intramural coronary artery (myocardial bridging)

Subendocardial coronary course

Coronary crossing

Anomalous origin of posterior descending artery from LAD or from a septal branch

Split RCA

Split LAD/dual LAD

Ectopic origination of first septal branch

Anomalies of coronary termination

Inadequate arteriolar/capillary ramifications

Fistulas from RCA, LCA, or conus artery

Anomalous anastomotic vessels

LAD: left anterior descending artery; RCA: right coronary artery; LCA: left coronary artery.

Significant coronary artery disease (CAD) was diagnosed when > 50% diameter stenosis was seen in one or more vessels or in a major branch [26]. Atherosclerotic involvement of anomalous coronary arteries was compared with normal coronary arteries of the same patients, which served as the control group. In cases with absent left main trunk, both left anterior descending artery (LAD) and left circumflex artery (LCX) were considered to be anomalous vessels. The hospital records of all patients with coronary anomalies were retrieved from the institutional database. These records were analyzed to study demographic factors, cardiovascular risk factors and clinical presentation.

Statistical analysis

Statistical analysis was done by using SPSS software Version 22.0 (SPSS Inc., Chicago, IL, USA). Data were presented as mean, standard deviation and as percentages. Chi-square test was used to compare the presence of significant CAD in anomalous and normal coronary arteries. A P value < 0.05 was considered as statistically significant.

Results

Out of 3,233 coronary angiograms analyzed, CAAs were found in 99 patients with an incidence of 3.06%.

Clinical characteristics of the patients

Mean age of the patients was 56.2 ± 12.9 years (range: 20 - 86 years). Seventy-four patients (74.75%) were males and 25 patients (25.25%) were females. Indication for CAG was acute coronary syndromes in 43 (43.43%) patients, stable IHD with exertion angina or dyspnea on exertion in 25 (25.25%) patients, atypical chest pain with electrocardiographic (ECG) or echocardiographic changes in 22 (22.22%) patients, heart failure or LV dysfunction in seven (7.07%) patients and workup prior to permanent pacemaker implantation (due to concomitant chest pain or dyspnea) in two (2.02%) patients. Considering the coronary risk factors, hypertension was present in 41 (41.41%) patients, diabetes mellitus in 33 (33.33%) patients, dyslipidemia in 19 (19.19%) patients and smoking in 26 (26.26%) patients (Table 2).

Table 2

Clinical Characteristics of 99 Patients With Coronary Anomalies

Clinical characteristics	N (%)
Gender
Male	74 (74.75%)
Female	25 (25.25%)
Indication for coronary angiography
Acute coronary syndromes	43 (43.43%)
Stable ischemic heart disease (angina/dyspnea on exertion)	25 (25.25%)
Atypical chest pain with Electrocardiographic/ Echocardiographic changes	22 (22.22%)
Heart failure or LV dysfunction	7 (7.07%)
Workup prior to pacemaker implantation	2 (2.02%)
Risk factors
Hypertension	41 (41.41%)
Diabetes mellitus	33 (33.33%)
Dyslipidemia	19 (19.19%)
Smoking	26 (26.26%)

LV: left ventricle.

Incidence and patterns of coronary anomalies

Out of 3,233 coronary angiograms analyzed, coronary anomalies were seen in 99 (3.06%) patients (Table 3). These anomalies were classified as per Angelini classification (Table 1 [22]).

Table 3

Incidence and Patterns of Coronary Anomalies in Our Study

Anomaly	N	Incidence (%)	Anomaly (%)
Total coronary angiographies	3,233
Total coronary anomalies	99	3.06
Anomalies of origin and distribution
Absent left main trunka	14	0.43	14.14
RCA from left sinusb	12	0.37	12.12
RCA from ascending aortaa	4	0.12	4.04
LCX from right sinus/RCAa	13	0.40	13.13
Anomalies of intrinsic coronary arterial anatomy
Split RCAa	27	0.84	27.27
Dual LADa	22	0.68	22.22
Superdominant LAD supplying PDAa	1	0.03	1.01
Anomalies of coronary termination
Coronary arterial fistulaec	6	0.18	6.06

aUsually benign. bPotentially serious. cSmall fistulae are usually benign, large or multiple fistulae can lead to serious manifestations. LAD: left anterior descending artery; RCA: right coronary artery; LCX: left circumflex artery; PDA: posterior descending artery.

Anomalies of origin and distribution

Absent left main trunk (Fig. 1) was seen in 14 patients, with angiographic incidence of 0.43% and anomaly incidence of 14.14%. Ectopic origin of right coronary artery (RCA) from left sinus (Fig. 2) was seen in 12 patients, with an angiographic incidence of 0.37%, and anomaly incidence of 12.12%. Ectopic origin of RCA from ascending aorta (Fig. 3) was seen in four patients, with an angiographic incidence of 0.12% and anomaly incidence of 4.04%. Ectopic origin of LCX from right sinus or RCA (Fig. 4) was noted in 13 patients, with an angiographic incidence of 0.40% and anomaly incidence of 13.13%.

Figure 1

Coronary angiogram in right anterior oblique (RAO) caudal projection showing absent left main trunk with separate origin of left anterior descending artery (LAD) and left circumflex (LCX) from left sinus.

Figure 2

Coronary angiogram in left anterior oblique (LAO) projection showing origin of right coronary artery (RCA) from left sinus. RCA had critical stenosis in mid segment with slow flow.

Figure 3

Coronary angiogram in left anterior oblique (LAO) projection showing origin of right coronary artery (RCA) from ascending aorta.

Figure 4

Coronary angiogram in left anterior oblique (LAO) projection showing ectopic origin of left circumflex artery (LCX) from right sinus.

Anomalies of intrinsic coronary arterial anatomy

Split RCA (Fig. 5) was the most common coronary anomaly detected in the study, being seen in 27 patients, with an angiographic incidence of 0.84% and anomaly incidence of 27.27%. Dual LAD (Fig. 6) was the second most common anomaly being seen in 22 cases with an angiographic incidence of 0.68% and anomaly incidence of 22.22%. Superdominant LAD supplying the posterior descending artery (PDA) (Fig. 7) was seen in one patient, with an angiographic incidence of 0.03% and anomaly incidence of 1.01%.

Figure 5

Coronary angiogram in anterior-posterior (AP) cranial projection showing split right coronary artery (RCA).

Figure 6

Coronary angiogram in right anterior oblique (RAO) cranial projection showing type I dual left anterior descending artery (LAD).

Figure 7

Coronary angiogram in right anterior oblique (RAO) cranial projection showing superdominant left anterior descending artery (LAD) continuing as posterior descending artery (PDA). Temporary pacing lead is seen in right ventricle (RV) apex as patient had third degree atrioventricular (AV) block.

Anomalies of coronary termination

Coronary artery fistulae were seen in six patients, with angiographic incidence of 0.18% and anomaly incidence of 6.06%. Two patients had fistulae from proximal RCA to right atrium (Fig. 8). One patient had fistula draining from proximal RCA into pulmonary artery branches, while another patient had fistula from proximal LAD into pulmonary artery. A unique case had bilateral fistulae with one fistula from proximal LAD into main pulmonary artery and another from proximal RCA into main pulmonary artery. One patient had fistula draining from proximal LCX into pulmonary artery branches. None of patients had symptoms attributable to coronary artery fistulae.

Figure 8

Coronary angiogram in left anterior-oblique (LAO) projection showing fistula from proximal right coronary artery (RCA), draining into right atrium (RA).

CAD in anomalous coronary arteries

Out of 99 patients with anomalous coronary arteries, 68 patients (68.7%) were found be having significant CAD; while 31 patients (31.31%) had normal epicardial coronaries or insignificant CAD. In patients with significant CAD triple vessel CAD was the most common pattern, being seen in 30 patients (30.3%). Single vessel disease was seen in 20 patients (20.2%), while double vessel disease was seen in 18 patients (18.18%). One patient (1.01%) had left main trunk involvement along with triple vessel disease. Fifty-three patients (53.54%) had significant CAD in anomalous vessels, out of which 11 patients (11.11%) had CAD restricted to anomalous vessels only. Fifteen patients (15.15%) had significant CAD only in normal vessels. Out of total 382 vessels of 99 patients; 268 were normal vessels and 114 vessels were anomalous. Significant CAD was seen in 89 of 268 (33.21%) normal vessels, whereas it was seen in 56 of 114 (49.12%) of anomalous vessels. This difference was statistically significant (P = 0.003), indicating CAD was more common in anomalous vessels than in normal vessels (Table 4).

Table 4

Atherosclerotic Involvement of Coronary Arteries in Our Study

	Total number	Percentage (%)
Total patients with CAAs	99	100
Normal coronaries/insignificant CAD	31	31.31
Significant CAD	68	68.69
Single vessel disease	20	20.20
Double vessel disease	18	18.18
Triple vessel disease	30	30.30
LMCA involvement	1	1.01
Patients with CAD in anomalous vessels	53	53.54
Patients with CAD only in normal vessels	15	15.15
Patients with CAD only in anomalous vessels	11	11.11

CAAs: coronary artery anomalies; CAD: coronary artery disease; LMCA: left main coronary artery.

Discussion

Clinical characteristics of patients

In our study, majority of patients with CAAs were males, which was similar to many previous studies [2, 3, 7-9, 24, 27-29]. This is probably due to more angiographies being performed in males. As we excluded the patients with congenital heart disease, the mean age in our study was 56.2 ± 12.9 years, and acute coronary syndromes were the most common indication for angiography in our study. Patients with CAAs had conventional CAD risk factors, with hypertension being the most common risk factor followed by diabetes mellitus. These findings are similar with many previous studies from India, probably reflecting the demographic profile of CAD in our country [24, 28, 29].

CAAs are a group of diverse disorders of coronary arterial anatomy which are rarely seen in general population. At present, there is no universally accepted definition and classification system of coronary anomalies. The classification system proposed by Angelini and coworkers is the most widely accepted classification system [22], which was followed in this study. Some authors do not consider coronary ectasia and myocardial bridging as coronary anomalies but rather consider these as variants of coronary anatomy [30-34]. Similarly, we also studied the incidence of CAAs excluding these variants.

The incidence of CAAs in the available literature (Table 5 [2, 3, 7-13, 23, 24, 27-29, 35-38]) is highly variable, and depends on several factors like characteristics of study population, definitions used and the type of imaging modality used. The incidence of CAAs in major angiographic studies has been reported to be 0.6% to 5.64% [2-13]. The incidence in the largest angiographic study by Yamanaka and Hobbs was 1.30%, while it was 5.64% in the prospective study by Angelini et al using strict diagnostic criteria [2, 10]. The incidence in our study was 3.06%, being higher than most of the previous studies but consistent with a few of these [10, 23, 28, 29]. Our results are closer to the prospectively conducted study by Angelini et al than most of the previous studies. This probably reflects the use of strict definitions and meticulous methodology in our study.

Table 5

Incidence and Patterns of Coronary Anomalies in Previous Studies

Author/year of publication	Incidence (%)	Most common anomaly	Imaging modality	Country
Yamanaka et al, 1990 [2]	1.30 (1,686 of 126,595)	Absent LM trunk with separate origin of LAD and LCX	CAG	USA
Kaku et al, 1996 [8]	0.31 (56 of 17,731)	Anomalous origin of RCA from LCS	CAG	Japan
Kardos et al, 1997 [7]	1.34 (103 of 7,694)	Absent LM trunk with separate origin of LAD and LCX	CAG	Central Europe
Garg et al, 2000 [9]	0.95 (39 of 4,100)	Anomalous origin of RCA from LCS/NCS	CAG	India
Angelini et al, 2002 [10]	5.64 (110 of 1,950)	Split RCA	CAG	USA
Yildiz et al, 2010 [3]	0.90 (112 of 12,457)	Absent LM trunk with separate origin of LAD and LCX	CAG	Turkey
Erol et al, 2011 [11]	1.96 (53 of 2,096)	Absent LM trunk with separate origin of LAD and LCX/origin of RCA from LCS	MDCT	Turkey
Fujimoto et al, 2011 [12]	1.52 (89 of 5,869)	Anomalous origin of RCA from LCS	MDCT	Japan
Sivri et al, 2012 [35]	0.74 (95 of 12,814)	Anomalous origin of LCX from RCS/RCA	CAG	Turkey
Sohrabi et al, 2012 [27]	1.30 (79 of 6,065)	Absent LM trunk with separate origin of LAD and LCX	CAG	Iran
Xu et al, 2012 [36]	1.02 (124 of 12,415)	Anomalous origin of RCA from LCS	CTCA	China
Yuksel et al, 2013 [13]	0.29 (48 of 16,573)	Anomalous origin of LCX from RCS/RCA	CAG	Turkey
Namgung et al, 2014 [37]	1.16 (103 of 8,864)	Anomalous origin of RCA from LCS	MDCT	Korea
Tharwat et al, 2014 [23]	2.7 (115 of 4,246)	Anomalous origin of LCX from RCS/RCA	CAG	Egypt
Altin et al, 2015 [38]	1.4 (78 of 5,548)	Absent LM trunk with separate origin of LAD and LCX	CAG	Turkey
Sivakumar et al, 2017 [28]	2.06 (32 of 1,547)	Anomalous origin of RCA from LCS	CAG	India
Somashekhara, 2017 [24]	0.65 (162 of 25,023)	Anomalous origin of RCA from LCS	CAG	India
Nawale et al, 2018 [29]	1.91 (86 of 4,481)	Anomalous origin of RCA from LCS/NCS	CAG	India

LM: left main; LAD: left anterior descending artery; LCX: left circumflex artery; RCA: right coronary artery; RCS: right coronary sinus; LCS: left coronary sinus; NCS: non-coronary sinus; CAG: catheter coronary angiography; MDCT: multidetector computed tomography.

In our study, the anomalies of intrinsic coronary anatomy were the most common type, with split RCA being the single most common type of CAA with an incidence of 0.84%. This result differs from most of the previous studies, but is consistent with the study by Angelini et al, who found split RCA to be the most common anomaly being present in 1.23% of the patients. This probably reflects the differences in definitions and methodologies being adopted by different investigators, leading to an underestimation of its true incidence.

Dual LAD was the second most common type of CAA in our study with an incidence of 0.68%. Although our results differ from most of the previous studies; the incidence of dual LAD in our study was close to what was found by Spindola-Franco et al who found 23 cases of dual LAD after analyzing 2,140 coronary angiograms, with an incidence of 1% [39]. Many large angiographic studies related to CAAs have not reported on incidence of dual LAD. Two large studies which reported dual LAD are by Nawale et al and Sirasapalli et al [29, 40]. Nawale et al found only a single case of dual LAD with an incidence of 0.02%. Sirasapalli et al found five cases of dual LAD after analyzing 8,021 computed tomography (CT) coronary angiograms with an incidence of 0.59%. We would like to attribute this to lack of uniform definitions or lack of awareness, resulting in under-recognition or under-reporting of the cases.

Absent left main trunk with separate origin of LAD and LCX from left sinus was the third most common anomaly detected in our study, with an incidence of 0.43%. The incidence of this anomaly in our study was similar to many previous studies who reported this to be the most common CAA, such as Yamanaka and Hobbs (0.41%), Erol and Seker (0.43%) and Yildiz et al (0.6%) [2, 3, 11].

Anomalous LCX originating from right sinus or RCA was seen in 13 cases in this study with an incidence of 0.4%. Although few studies have reported this is to be the most common type of CAA (Table 5), the incidence rate of this anomaly in our results was similar to many studies like Yamanaka and Hobbs (0.37%), Erol and Seker (0.43%), Nawale et al (0.33%) and Sivri et al (0.36%) [2, 11, 29, 35].

Anomalous origin of RCA from left sinus is a potentially serious coronary anomaly. This anomaly can result in myocardial ischemia and life-threatening clinical manifestations like myocardial infarction, ventricular tachycardia, syncope and sudden death in the absence of significant atherosclerosis [2]. Although exact pathophysiological basis for this association is unclear, many authors have suggested different mechanisms. Yamanaka and Hobbs suggested that compression of proximal RCA by great arteries due to its inter-arterial course between aorta and pulmonary is responsible for myocardial ischemia at the time of exercise [2]. Taylor et al have proposed that acute angled takeoff of RCA from left sinus results in slit-like orifice, which can collapse in a valve-like manner leading to myocardial ischemia [41]. Kaku et al have suggested that proximal RCA situated between aorta and pulmonary artery is prone to compression or kinking phenomenon, resulting in intimal disruption and vasospasm; thus explaining the occurrence of myocardial ischemia in some patients at rest or low levels of exercise [42]. In our study anomalous origin of RCA from left sinus of Valsalva was present in 12 patients, with an angiographic incidence of 0.37%. We did not encounter any life-threatening clinical manifestations in these patients except for a single case. Although this patient presented with isolated right ventricular infarction leading to heart failure, this was attributable to atherosclerotic occlusion of anomalous non-dominant mid RCA; rather than due to compression of anomalously arising proximal RCA. Many studies have reported this anomaly to be the most common type of CAA (Table 5). Although, this was not the case in our study; the incidence rate in our study was similar to many of the previously published studies like Kaku et al (0.32%), Garg et al (0.37%), Fujimoto et al (0.46%) and Namgung and Kim (0.46%) [8, 9, 12, 37].

Anomalous origin of RCA from ascending aorta was seen in this study in four patients, with an incidence of 0.12%. This was similar to that seen in study by Yamanaka and Hobbs (0.15%), although lower than reported by Nawale et al (0.33%) [2, 29].

In this study, we encountered a very rare case of super-dominant LAD continuing beyond the cardiac apex as large PDA; with an incidence of 0.03%. This extremely rare anomaly, also known as hyper-dominant LAD or type IV LAD; has only been sporadically reported in the literature in the form of case reports and has never been described in a large angiographic series [43-48]. In this anomaly, RCA is usually small and atretic, with a large PDA originating as continuation of distal LAD in posterior interventricular sulcus and supplying the inferior myocardial segments. This anomaly is usually considered benign, except in cases of atherosclerotic occlusion of LAD leading to extensive infarctions in anterior and inferior segments with its attendant complications like heart failure or cardiogenic shock.

Coronary artery fistulae are abnormal communications between one or more coronary arteries and the cardiac chambers or another blood vessel, such as vena cave, coronary sinus, pulmonary artery and bronchial veins. Incidence of coronary artery fistulae has been reported to range from 0.05% to 0.9% in several large selected series [49, 50]. RCA is considered as the most common site of origin of these fistulae and right-sided cardiac chambers and vessels are the most common site of termination [51]. Most of the fistulae are small without any hemodynamic consequences, and are detected incidentally on echocardiography or cardiac catheterization. However in some cases, large fistulae lead to significant shunts and can cause pulmonary hypertension, heart failure, coronary steal phenomenon or rupture of the fistula. In our study fistulae were seen in six cases, with an incidence of 0.18%. This incidence rate is similar to that seen in many studies, such as by Yamanaka and Hobbs (0.17%), Tharwat et al (0.21%), Namgung and Kim (0.15%) [2, 23, 37]. In our study RCA was the most common site of origin of coronary fistulae, and pulmonary artery was the most common site of termination. All of the fistulae in our study were small without causing any significant shunting and hence were considered benign.

Atherosclerosis of anomalous coronaries

The issue of atherosclerotic involvement of anomalous coronary arteries has generated considerable interest as well as controversy in the literature, with its incidence ranging from 1.7% to 72.2% in various studies [8, 9, 23, 29, 52, 53]. In our study, atherosclerotic involvement of anomalous coronaries was noted in 53.54% of patients with CAAs. These results are similar to study by Nawale et al who found an incidence rate of 52.32% [29].

However, our results differ from Nawale et al in the aspect that we found atherosclerotic involvement to be more frequent in anomalous vessels, whereas their study showed rates of atherosclerosis to be similar in anomalous and normal coronaries. Our results are in agreement with Tharwat et al and Somashekhara who observed that CAAs are more frequently involved in atherosclerosis than the normal coronaries [23, 24]. In contrast, some studies have shown rates of atherosclerosis to be lower in anomalous coronaries than the normal coronaries [52, 54, 55].

Limitations

Being a single-center, retrospective study of patients undergoing catheter CAG, our study had a referral bias and may not represent the general population. Our study population predominantly consisted of middle age adult population with acute coronary syndromes being the most common indication for CAG, incidence of CAAs in general population may have been underestimated. In our study, the rates of atherosclerotic involvement of anomalous coronaries were compared with normal coronaries of the same patients and not with those of patients without anomalous coronaries. We believe that large prospective studies are needed to look into the relation between atherosclerosis and anomalous coronary arteries.

Conclusions

CAAs are a rare group of disorders of coronary anatomy which are mostly detected incidentally on CAG or autopsy. The incidence of CAAs in our study was slightly higher than many of the previous angiographic series. The patterns of coronary anomalies in our study were different from most of the previous studies, with split RCA being the most common anomaly in this study. Interestingly, our study had higher incidence of atherosclerotic involvement of anomalous vessels as compared to normal vessels; which is contrary to many of the previous studies.