Aim: To estimate the real-world incidence and timing of radiation pneumonitis following chemoradiotherapy for Stage III non-small-cell lung cancer and compare costs between patients with and without radiation pneumonitis. Methods: Retrospective analysis using the Symphony Health Integrated Dataverse. Results: Pneumonitis incidence was 12.4% with a 177-day mean time to onset. Patients with versus without pneumonitis were more frequently admitted to the hospital (33.8 vs 19.2%, p < 0.0001) and seen in the emergency room (51.9 vs 35.8%, p < 0.0001) and had higher mean total healthcare costs (US$4251 vs US$3969 per-patient per-month; p = 0.0163). Conclusion: Although pneumonitis significantly increased healthcare resource utilization and costs in chemoradiotherapy-treated Stage III non-small-cell lung cancer, the per-patient per-month differential was <10%. Such financial assessments are critical for cost-benefit analysis.
Aim: To estimate the real-world incidence and timing of radiation pneumonitis following chemoradiotherapy for Stage III non-small-cell lung cancer and compare costs between patients with and without radiation pneumonitis. Methods: Retrospective analysis using the Symphony Health Integrated Dataverse. Results:Pneumonitis incidence was 12.4% with a 177-day mean time to onset. Patients with versus without pneumonitis were more frequently admitted to the hospital (33.8 vs 19.2%, p < 0.0001) and seen in the emergency room (51.9 vs 35.8%, p < 0.0001) and had higher mean total healthcare costs (US$4251 vs US$3969 per-patient per-month; p = 0.0163). Conclusion: Although pneumonitis significantly increased healthcare resource utilization and costs in chemoradiotherapy-treated Stage III non-small-cell lung cancer, the per-patient per-month differential was <10%. Such financial assessments are critical for cost-benefit analysis.
Entities:
Keywords:
burden of disease; chemoradiotherapy; cost; non-small-cell lung cancer; pneumonitis
Authors: Shane S Neibart; Daniella E Portal; Jyoti Malhotra; Salma K Jabbour; Jason A Roy; Brian L Strom Journal: Pharmacoepidemiol Drug Saf Date: 2021-08-23 Impact factor: 2.890
Authors: Tithi Biswas; Afshin Dowlati; Charles A Kunos; John J Pink; Nancy L Oleinick; Shakun Malik; Pingfu Fu; Shufen Cao; Debora S Bruno; David L Bajor; Monaliben Patel; Stanton L Gerson; Mitchell Machtay Journal: Clin Cancer Res Date: 2022-02-15 Impact factor: 13.801