Human-in-the-Loop Insulin Dosing.

The last ten years of efforts in developing automated insulin dosing systems have led to one hybrid closed-loop device in the US market with more in the late stages of development. Much of the focus has been on algorithms, including closed-loop, detection of sensor and pump faults, and safety. There has been less discussion in the open literature about user interface design and related options. This article provides perspectives on automated insulin delivery (AID) system design by analyzing commonly used devices, such as bicycles and car entertainment systems. The recent Boeing 737 Max 8 disasters are used to highlight related challenges with AID systems. The role that system engineers can play in the do it yourself artificial pancreas system movement is also discussed. The human-in-the-loop remains by far the most important "component" of any AID system.