Akane Yamabe1,2, Atsushi Irisawa3,4, Manoop S Bhutani5, Ai Sato1,2, Takumi Maki1, Yusuke Takasaki6, Yoshitsugu Yoshida1, Shogo Yamamoto1, Goro Shibukawa1. 1. Department of Gastroenterology, Dokkyo Medical University School of Medicine, Tochigi, Japan. 2. Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Fukushima, Japan. 3. Department of Gastroenterology, Dokkyo Medical University School of Medicine, Tochigi, Japan, irisawa@dokkyomed.ac.jp. 4. Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Fukushima, Japan, irisawa@dokkyomed.ac.jp. 5. Department of Gastroenterology, Hepatology and Nutrition-Unit, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 6. Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
Abstract
BACKGROUND: The diagnosis of chronic pancreatitis (CP) using endoscopic ultrasound (EUS) criteria, referred to as the Rosemont classification (RC), has been widely performed. However, the validity of the RC, which was based on expert opinion, is still controversial. If EUS findings are associated with CP, then they should be associated with risk factors for CP. In this study, to verify the appropriateness of the RC and each EUS finding, we performed a retrospective analysis from the viewpoint of risk factors for CP. SUMMARY: Three hundred and forty-four patients were enrolled in this study. Clinical background characteristics that associate with CP were alcohol intake, smoking, history of acute pancreatitis (AP), and age. The correlation between EUS criteria for CP and clinical background was investigated. All EUS findings except the presence of cysts showed significant correlations with one or 2 of the 3 following factors: ethanol (EtOH) intake, smoking status, and history of AP. Results of the univariate and multivariate analyses showed that 3 factors (EtOH intake, smoking, and history of AP) other than age were positively correlated with the RC. Moreover, the risk of progression from normal to consistent CP to indeterminate and suggestive CP was found to increase with increasing EtOH intake. Key Messages: The RC and each EUS finding was validated from the viewpoint of risk factors for CP.
BACKGROUND: The diagnosis of chronic pancreatitis (CP) using endoscopic ultrasound (EUS) criteria, referred to as the Rosemont classification (RC), has been widely performed. However, the validity of the RC, which was based on expert opinion, is still controversial. If EUS findings are associated with CP, then they should be associated with risk factors for CP. In this study, to verify the appropriateness of the RC and each EUS finding, we performed a retrospective analysis from the viewpoint of risk factors for CP. SUMMARY: Three hundred and forty-four patients were enrolled in this study. Clinical background characteristics that associate with CP were alcohol intake, smoking, history of acute pancreatitis (AP), and age. The correlation between EUS criteria for CP and clinical background was investigated. All EUS findings except the presence of cysts showed significant correlations with one or 2 of the 3 following factors: ethanol (EtOH) intake, smoking status, and history of AP. Results of the univariate and multivariate analyses showed that 3 factors (EtOH intake, smoking, and history of AP) other than age were positively correlated with the RC. Moreover, the risk of progression from normal to consistent CP to indeterminate and suggestive CP was found to increase with increasing EtOH intake. Key Messages: The RC and each EUS finding was validated from the viewpoint of risk factors for CP.